ArticleMicrobiology spectrum2025
Integrated multi-omics identifies dysregulated lipid metabolism of paresis in dairy sheep during the early transition period.
Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Effects of Prepartum Supplementation with Flaxseed and Black Soldier Fly Larvae Oils on Fatty Acid Composition and Lipid Quality Indices in Sheep Milk.Molecules (Basel, Switzerland) · 2026Article
- Nonlinear association of HbA1c/HDL-C ratio with heart failure in adults: a large cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paresis during the early transition period is a prevalent metabolic disorder in prolific dairy sheep, characterized by a complex and poorly understood pathogenesis. This study longitudinally monitored a cohort of dairy sheep from 21 days antepartum to 1 day postpartum. During this period, blood, fecal, and colostrum samples were collected. The pathway of paresis was revealed by plasma metabolome and fecal 16S sequencing, and potential early biomarkers were identified. The physiological parameters of healthy dairy sheep (HDS) and paretic dairy sheep (PDS) differed in both the antepartum (not yet paresis) and postpartum (paresis) periods. Elemental analysis revealed higher levels of copper, potassium, and magnesium in PDS colostrum compared to HDS. Metabolomic analysis of HDS and PDS in antepartum identified 37 differential metabolites, with acylcarnitines (3-hydroxyhexadecadienoylcarnitine and 3-hydroxyoctanedioylcarnitine) emerging as promising early diagnostic biomarkers. 16S rRNA sequencing revealed distinct microbial signatures, with genera such as
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