Evidence map›Paper›PMID 41065365›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2025

Discovery of new aurone derivatives as submicromolar CK2 inhibitors.

Mykhailo V Mahdysiuk, Galyna P Volynets, Volodymyr G Bdzhola, Oleksandr A Bieda, Sergiy S Lukashov, Vladislav M Sapelkin, Leonid L Karbovskyi, Sergiy M Yarmoluk

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Article in Journal of enzyme inhibition and medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Mykhailo V MahdysiukInstitute of Molecular Biology and Genetics, Kyiv, Ukraine.
Galyna P VolynetsInstitute of Molecular Biology and Genetics, Kyiv, Ukraine.
Volodymyr G BdzholaInstitute of Molecular Biology and Genetics, Kyiv, Ukraine.
Oleksandr A BiedaInstitute of Molecular Biology and Genetics, Kyiv, Ukraine.
Sergiy S LukashovInstitute of Molecular Biology and Genetics, Kyiv, Ukraine.
Vladislav M SapelkinInstitute of Molecular Biology and Genetics, Kyiv, Ukraine.
Leonid L KarbovskyiBiotech API Laboratory, Kyiv, Ukraine.
Sergiy M YarmolukInstitute of Molecular Biology and Genetics, Kyiv, Ukraine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein kinase CK2 is a promising therapeutic target, and this study explores 54 aurone derivatives as potential CK2 inhibitors. Activity was evaluated using luminescent and capillary electrophoresis assays, identifying 17 compounds with submicromolar activity. The most potent inhibitors shared key structural features: a benzo group on the A-ring, a hydrogen bond acceptor at the R4' position, and an additional substituent at the R3' position of the B-ring. Molecular docking revealed similar binding modes among active compounds, with interactions involving Leu45, Val53, Val66, Met163, Phe113, Lys68, and Ile174. Notably, BFO25 showed the highest activity (IC

Indexed as

BenzofuransCasein Kinase IIDrug DiscoveryProtein Kinase InhibitorsDose-Response Relationship, DrugHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipauroneBenzofuransCasein Kinase IIProtein Kinase Inhibitorscapillary electrophoresisEnzyme inhibitionluminometrymolecular dockingprotein kinase

Identifiers

PMID41065365
PMCPMC12512767

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.