Evidence map›Paper›PMID 41065299›Full record

SynthesisBiomarkers in medicine2025

Evidence-based medical evidence: non-coding RNAs serve as prognostic biomarkers for gastric cancer.

Zhiren Zhou, Hongkun Ma, Yanan Liu, Xueqing Zhang, Xiaojing Huang, Zheng Li, Huanyu Ren, Huiru Niu, Hao Liao, Xiaojing Zhang and 3 more

Abstract readMeta-AnalysisSystematic Review
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In one paragraph

Synthesis in Biomarkers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Zhiren ZhouPublic Health School, Mudanjiang Medical University, Mudanjiang, China.
Hongkun MaPublic Health School, Mudanjiang Medical University, Mudanjiang, China.
Yanan LiuPublic Health School, Mudanjiang Medical University, Mudanjiang, China.
Xueqing ZhangPublic Health School, Mudanjiang Medical University, Mudanjiang, China.
Xiaojing HuangPublic Health School, Mudanjiang Medical University, Mudanjiang, China.
Zheng LiPublic Health School, Mudanjiang Medical University, Mudanjiang, China.
Huanyu RenPublic Health School, Mudanjiang Medical University, Mudanjiang, China.
Huiru NiuPublic Health School, Mudanjiang Medical University, Mudanjiang, China.
Hao LiaoPublic Health School, Mudanjiang Medical University, Mudanjiang, China.
Xiaojing ZhangPublic Health School, Mudanjiang Medical University, Mudanjiang, China.
Hongzhi PanCollaborative Research Center, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Lina ZouNursing School, Mudanjiang Medical University, Mudanjiang, China.
Shengzhong RongPublic Health School, Mudanjiang Medical University, Mudanjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThere are meta-analyses about the correlation between non-coding RNA and the prognosis of gastric cancer, which are focus on a single or a particular type of non-coding RNA. This study aims to verify the correlation between various non-coding RNAs and the prognosis of gastric cancer through meta-analysis.

methodsThe studies documenting the association between non-coding RNAs and the prognosis of gastric cancer up until September 2023 were extracted. The outcomes of the univariate and multivariate analyses were combined for each noncoding RNA. Sources of heterogeneity were determined by meta-regression analysis, and publication bias was assessed using the Egger test.

resultsFifty-five studies were included in meta-analysis, of which 40 reported miRNAs and 14 reported lncRNAs. The up-regulation of miR-17-5p, miR-21, miR-214, miR-20a, lnc-CECR7, lnc-SNHG15, lnc-Sox2ot, lnc-ANRIL, lnc-DSCR8, lnc-ZEB1-AS1 and lnc-NEAT1 were associated with an unfavorable OS in gastric cancer. Elevated level of lnc-PVT1 correlated with an adverse DFS in gastric cancer. A diminished expression of miR-133a, miR-141, miR-206, and miR-1236-3p predicted a poor OS of gastric cancer.

conclusionsVarious non-coding RNAs are associated with the prognosis of gastric cancer based on new evidence-based medical evidence, which provides a potential value for clinical diagnosis and treatment.

Indexed as

Biomarkers, TumorEvidence-Based MedicineRNA, Long NoncodingStomach NeoplasmsGene Expression Regulation, NeoplasticHumansMicroRNAsPrognosisBiomarkers, TumorMicroRNAsRNA, Long NoncodingGastric cancerlncRNAmeta-analysismiRNAnon-coding RNAprognosis

Identifiers

PMID41065299
PMCPMC12542616

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.