SynthesisJournal of the American Heart Association2025
Thrombectomy for Distal Medium Vessel Occlusion: A Meta-Analysis of Randomized Controlled Trials.
Synthesis in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- MeVO: To Treat or Not To Treat? Review of the Latest Evidence.Current neurology and neuroscience reports · 2026Review
- Stent retrievers for acute ischemic stroke: technological advances, clinical applications, and future perspectives.Journal of neurology · 2026Review
- Efficacy and safety of early tirofiban administration after intravenous thrombolysis in patients with acute ischaemic stroke: the multicentre, randomised, double-blind, placebo-controlled RESCUE BT3 trial protocol.European stroke journal · 2026Article
- CEREGLIDE 71 catheter for contact aspiration of secondary distal medium vessel occlusion: A case report.Radiology case reports · 2026Article
- Neurointerventional Advances in 2025.Stroke (Hoboken, N.J.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApproximately 25% to 40% of all acute ischemic strokes result from distal medium vessel occlusions. However, the effectiveness and safety of thrombectomy for distal medium vessel occlusions remain uncertain.
methodsA systematic search of PubMed, Cochrane, and Embase was conducted for randomized controlled trials published until February 2025. The primary outcomes were functional outcomes at 90 days (excellent, good, and favorable). The secondary outcomes included symptomatic intracranial hemorrhage (ICH), any ICH, and mortality at 90 days.
resultsThree studies involving 1246 patients with stroke with distal medium vessel occlusion were included (614 patients receiving thrombectomy; others with medical management). At 3 months, the odds ratio for an excellent functional outcome was 0.92 (95%, 0.72-1.17), for a good functional outcome was 0.87 (95% CI, 0.70-1.09), and for a favorable functional outcome was 0.84 (95% CI, 0.64-1.10), indicating no significant difference between the 2 groups. However, thrombectomy was associated with a higher risk of hemorrhage, with an odds ratio of 2.18 (95% CI, 1.24-3.83) for symptomatic ICH and 1.96 (95% CI, 1.54-2.50) for any ICH. Mortality at 3 months was similar between the groups, with an odds ratio of 1.20 (95% CI, 0.85-1.70).
conclusionsThrombectomy did not significantly improve functional outcomes or reduce mortality but increased symptomatic ICH and any ICH. Further recent randomized controlled trials are needed to define subgroups that may benefit. REGISTRATION: PROSPERO CRD420251073344.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.