Evidence map›Paper›PMID 41065245›Full record

ArticleJournal of the American Heart Association2025

Clinical Characteristics, Hemodynamic Profile, and Outcomes in Patients With Low-Gradient and High-Gradient Severe Mitral Stenosis: Influence of Flow Status.

Ryan Leow, Meei-Wah Chan, Tony Yi-Wei Li, William Kf Kong, Kian-Keong Poh, Ivandito Kuntjoro, Ching-Hui Sia, Tiong-Cheng Yeo

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ryan LeowDepartment of Cardiology National University Heart Centre Singapore Singapore.ORCID 0000-0002-7730-3144
Meei-Wah ChanDepartment of Cardiology National University Heart Centre Singapore Singapore.
Tony Yi-Wei LiDepartment of Cardiology National University Heart Centre Singapore Singapore.ORCID 0000-0002-1234-1334
William Kf KongDepartment of Cardiology National University Heart Centre Singapore Singapore.
Kian-Keong PohDepartment of Cardiology National University Heart Centre Singapore Singapore.ORCID 0000-0003-3515-7924
Ivandito KuntjoroDepartment of Cardiology National University Heart Centre Singapore Singapore.ORCID 0000-0001-7335-2312
Ching-Hui SiaDepartment of Cardiology National University Heart Centre Singapore Singapore.ORCID 0000-0002-2764-2869
Tiong-Cheng YeoDepartment of Cardiology National University Heart Centre Singapore Singapore.ORCID 0000-0002-2374-1069

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn severe mitral stenosis (MS), flow-status was recently recognized as potentially impactful in some patients with low transmitral gradients.

methodsWe studied 172 patients with isolated rheumatic MS with mitral valve area ≤1.5 cm

resultsForty-three (25.0%) patients had NF low-gradient MS, 60 (34.9%) had LF low-gradient MS, 26 (15.1%) had NF high-gradient MS, and 43 (25.0%) had LF high-gradient MS. Patients with LF status were more symptomatic (

conclusionsPatients with LF severe MS demonstrated a characteristic pattern of echocardiographic abnormalities and poorer outcomes regardless of transmitral gradients.

Indexed as

HemodynamicsMitral ValveMitral Valve StenosisRheumatic Heart DiseaseAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesSeverity of Illness IndexStroke VolumeVentricular Function, Rightlow‐flow mitral stenosismitral stenosisrheumatic heart disease

Identifiers

PMID41065245
PMCPMC12684528

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.