ArticleThe Laryngoscope2026
Polyphenolic Activation of Basophils Explains Alcohol Hypersensitivity in AERD.
Article in The Laryngoscope, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Special Issue "Flow Cytometry: Applications and Challenges".International journal of molecular sciences · 2026Article
- Polyphenolic Activation of Basophils Explains Alcohol Hypersensitivity in AERD.The Laryngoscope · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
objectiveAlcohol hypersensitivity (AH), an exacerbation of respiratory symptoms in response to alcohol consumption, is common in aspirin-exacerbated respiratory disease (AERD) and other forms of chronic rhinosinusitis (CRS). The mechanism of this is unknown. This study investigates the ability of polyphenolic compounds in alcoholic beverages to activate innate immune cells as a means of explaining AH in AERD.
methodsData were collected from 478 consecutive adults presenting to a tertiary care sinonasal clinic in whom the presence of AH and their CRS phenotype was determined. A subset of these individuals was invited to provide whole blood samples on which the effects of ethanol, red wine extract (RWE), and individual polyphenolic compounds were explored. Granulocyte activation was quantified by flow cytometry as upregulation of CD63 during the Basophil Activation Test (BAT). Additionally, secretion of lipid metabolites was measured by enzyme immunoassays (EIAs).
resultsTwelve patients with CRSwNP were compared to age and sex-matched healthy controls. A dose-dependent stimulation of basophil degranulation was noted with RWE and epigallocatechin (p < 0.05). No activation was noted in healthy controls or subjects to ethanol. Catechin demonstrated a dose-dependent, but only near-significant difference (p = 0.07) in basophil degranulation compared to controls.
conclusionsPolyphenolic compounds, and not ethanol, can trigger the activation and degranulation of eosinophils and basophils, and this may explain the sensitivity to alcoholic beverages seen in patients with AERD and CRSwNP. LEVEL OF EVIDENCE: NA.
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