Evidence map›Paper›PMID 41065085›Full record

ArticleJournal of neurogenetics2025

Simultaneous recording of spikes and calcium signals in odor-evoked responses of

Yiyi Xiao, Shiuan-Tze Wu, Yinan Xuan, Scott A Rifkin, Chih-Ying Su

Abstract read
In one paragraph

Article in Journal of neurogenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Intrinsic Diversity in Odor-Evoked Calcium Rises acrossThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yiyi XiaoDepartment of Neurobiology, University of California San Diego, La Jolla, CA, USA.ORCID 0009-0001-1520-1863
Shiuan-Tze WuDepartment of Neurobiology, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-8445-1882
Yinan XuanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Scott A RifkinDepartment of Ecology, Behavior, and Evolution, University of California San Diego, La Jolla, CA, USA.
Chih-Ying SuDepartment of Neurobiology, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-0005-1890

Funding

NEUROBIOLOGY TRAINING PROGRAMT32NS007220 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIN, YISHI · 1985 to 2023
$4.5M
Genetic analysis of state-dependent chemosensory processingR01DC016466 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SU, CHIH-YING · 2017 to 2025
$3.6M
Olfactory neuromodulation: genes, cells, and behaviorR01DC021551 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI William J Joiner · 2024 to 2026
$1.5M
The relationship between spike response and calcium fluorescent signal in insect olfactory receptor neuronsR21AI169343 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SU, CHIH-YING · 2022 to 2023
$435k
Analysis of sensory dendrite morphology and its impact on olfactory sensitivityR21DC020536 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SU, CHIH-YING · 2022 to 2023
$435k
NIAID NIH HHS R21 AI169343NIDCD NIH HHS R01 DC016466NIDCD NIH HHS R01 DC021551NIDCD NIH HHS R21 DC020536NINDS NIH HHS T32 NS007220
6 · The paper itself

Abstract

Most insects, including agricultural pests and disease vectors, rely on olfaction for key innate behaviors. Consequently, there is growing interest in studying insect olfaction to gain insights into odor-driven behavior and to support efforts in vector control. Calcium imaging using GCaMP fluorescence is widely used to identify olfactory receptor neurons (ORNs) responsive to ethologically relevant odors. However, accurate interpretation of GCaMP signals in the antenna requires understanding both response uniformity within an ORN population and how calcium signals relate to spike activity. To address this, we optimized a dual-modality recording method combining single-sensillum electrophysiology and widefield imaging for

Indexed as

Action PotentialsArthropod AntennaeCalcium SignalingOdorantsOlfactory Receptor NeuronsSmellAnimalsCalciumDrosophilaCalciumdual-modality recordingOlfactory receptor neuronssingle-sensillum recordingwidefield calcium imaging

Identifiers

PMID41065085
PMCPMC13088990

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.