Evidence map›Paper›PMID 41065044›Full record

ArticleBasic & clinical pharmacology & toxicology2025

Development of a Brief Mindfulness-Informed Cognitive-Behavioural Therapy Intervention to Pair With Pharmacist-Led Benzodiazepine Tapering for Older Adults: The CSTARS Intervention.

Kristen M Kraemer, Brianna Wang, Marissa McCann, Julia Lindenberg, Timothy S Anderson, Gloria Y Yeh

Abstract read
In one paragraph

Article in Basic & clinical pharmacology & toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kristen M KraemerDivision of General Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-5532-0111
Brianna WangDivision of General Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-9567-9233
Marissa McCannDivision of General Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Julia LindenbergDivision of General Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Timothy S AndersonDivision of General Internal Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Gloria Y YehDivision of General Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Funding

U.S. Deprescribing Research NetworkR24AG064025 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BOYD, CYNTHIA MELINDA, STEINMAN, MICHAEL A. · 2019 to 2023
$9.9M
Mentoring and Patient-Oriented Research in Mind-Body ExerciseK24AT009465 · NCCIH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GLORIA Y YEH · 2017 to 2026
$1.3M
Optimizing prescribing decisions for hospitalized older adults with chronic conditionsK76AG074878 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Timothy S Anderson · 2022 to 2026
$1.2M
Understanding components of mind-body exercise for physical activity engagement in metabolic syndromeK23AT011043 · NCCIH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KRAEMER, KRISTEN · 2021 to 2025
$814k
NCCIH NIH HHS K23 AT011043NCCIH NIH HHS K24 AT009465NIA NIH HHS K76 AG074878NIA NIH HHS R24 AG064025US Deprescribing Research Network through the National Institute on Aging and National Center for Complementary and Integrative Health R24AG064025
6 · The paper itself

Abstract

Benzodiazepines are potentially inappropriate medications for older adults, and deprescribing interventions are needed. We describe the development of a psychologist-led, mindfulness-informed cognitive-behavioural therapy (CBT) intervention to pair with pharmacist-led tapering to support benzodiazepine deprescribing in older adults. Based on previous research, we first developed an intervention conceptual model. The aim of this study was to (1) gather stakeholder feedback on previous experiences with benzodiazepine tapering and on our intervention model and proposed intervention, and (2) integrate this qualitative feedback to develop an intervention manual. We conducted (a) semistructured individual interviews with older adults (N = 8) who previously attempted to taper their benzodiazepines, and (b) a focus group with members (N = 5) from a national deprescribing patient stakeholder group. Overlapping themes emerged, including support for the mindfulness-informed CBT intervention, the importance of control over taper pace, the need for a goal- and skills-oriented intervention, the importance of normalizing side effects of the taper and building confidence to manage side effects and the utility of fostering acceptance during the taper. These findings informed the development of a final intervention manual, named Confidence-Building Strategies for Reducing Sedative Medications (CSTARS), to be tested in a single-arm pilot feasibility trial.

Indexed as

BenzodiazepinesCognitive Behavioral TherapyDrug TaperingMindfulnessPharmacistsAgedAged, 80 and overDeprescriptionsFemaleFocus GroupsHumansInappropriate PrescribingMaleMiddle AgedBenzodiazepinesbenzodiazepinecognitive–behavioural therapydeprescribingmindfulnesstapering

Identifiers

PMID41065044
PMCPMC12667232

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.