Evidence map›Paper›PMID 41064882›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid-Liquid Phase Separation in Caenorhabditis elegans.

Yuhang Luo, Hongbo Xu, Pei Peng, Xinhe Lu, Qian Zhou, Ziqing Gao, Cheng Tang, Hongyan Yin, Ying Cai, Gaga Mahai and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuhang LuoSchool of Environmental Science and Engineering, Hainan University, Haikou, China.
Hongbo XuDepartment of Critical Care Medicine, Huazhong University of Science and Technology Union, Wuhan, China.
Pei PengSchool of Environmental Science and Engineering, Hainan University, Haikou, China.
Xinhe LuSchool of Environmental Science and Engineering, Hainan University, Haikou, China.
Qian ZhouSchool of Environmental Science and Engineering, Hainan University, Haikou, China.
Ziqing GaoSchool of Environmental Science and Engineering, Hainan University, Haikou, China.
Cheng TangSchool of Environmental Science and Engineering, Hainan University, Haikou, China.
Hongyan YinSchool of Tropical Agriculture and Forestry, Hainan University, Haikou, China.
Ying CaiSchool of Environmental Science and Engineering, Hainan University, Haikou, China.
Gaga MahaiSchool of Environmental Science and Engineering, Hainan University, Haikou, China.
Zhiqiang ZhuSchool of Environmental Science and Engineering, Hainan University, Haikou, China.
Zuojun LiuSchool of Environmental Science and Engineering, Hainan University, Haikou, China.
Hanzeng LiSchool of Environmental Science and Engineering, Hainan University, Haikou, China.ORCID https://orcid.org/0009-0002-2075-1613
Shunqing XuSchool of Environmental Science and Engineering, Hainan University, Haikou, China.ORCID https://orcid.org/0000-0002-7771-3821

Funding

Collaborative Innovation Center of One Health, Hainan University XTCX2022JKA02Innovation Fund for Scientific and Technological Personnel of Hainan Province KJRC2023B02National Natural Science Foundation of China 22466015Natural Science Foundation of Hainan Province 823QN230
6 · The paper itself

Abstract

Polyhalogenated carbazoles (PHCZ) are emerging organic pollutants derived from a variety of natural and synthetic sources. While PHCZ have raised environmental concerns due to its persistence, bioaccumulation, and widespread distribution, its neuronal toxicity remains largely understudied. Here, the general and neuronal toxicity of PHCZ using the model organism Caenorhabditis elegans (C. elegans) is evaluated. It is found that PHCZ can induce significant dopaminergic neurodegeneration, in addition to exhibiting general toxicity affecting development and male gamete differentiation. Mechanistically, PHCZ promote liquid-liquid phase separation (LLPS) of the Parkinson's disease (PD)-associated protein α-synuclein (α-syn), and reduces the fluidity of the resultant condensate both in vitro and in vivo. PHCZ disrupts general protein homeostasis and specifically activates the unfolded protein response in the ER (UPR

Indexed as

Caenorhabditis elegansCarbazolesDopaminergic Neuronsalpha-SynucleinAnimalsCaenorhabditis elegans ProteinsPhase SeparationUnfolded Protein Responsealpha-SynucleinCaenorhabditis elegans ProteinsCarbazolesCaenorhabditis elegansliquid–liquid phase separation (LLPS)polyhalogenated carbazolestoxicologyunfolded protein responses

Identifiers

PMID41064882
PMCPMC12752670

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.