Evidence map›Paper›PMID 41064861›Full record

Trial reportHypertension (Dallas, Tex. : 1979)2025

Systolic Blood Pressure Time in Target Range and Acute Kidney Injury in Patients With Hypertension.

Wei-Hua Chen, Cheng Yang, Yi-Tian Chen, Zi-Jin Li, Kai Guan, Jian-Jun Li, Rong-Chong Huang

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01206062 (Systolic Blood Pressure Intervention Trial), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01206062 nacompletednot on this map

Systolic Blood Pressure Intervention Trial

TypeinterventionalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran2010 to 2019Enrolled9,361ConditionsHypertensionArmsIntensive control of SBP, Standard control of SBP
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wei-Hua Chen *Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, China (W.-H.C., Y.-T.C., Z.-J.L., R.-C.H.).ORCID 0000-0002-7670-4165
Cheng Yang *Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing (C.Y., K.G.).ORCID 0009-0008-4454-5711
Yi-Tian ChenDepartment of Cardiology, Beijing Friendship Hospital, Capital Medical University, China (W.-H.C., Y.-T.C., Z.-J.L., R.-C.H.).
Zi-Jin LiDepartment of Cardiology, Beijing Friendship Hospital, Capital Medical University, China (W.-H.C., Y.-T.C., Z.-J.L., R.-C.H.).
Kai GuanDepartment of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing (C.Y., K.G.).
Jian-Jun LiCardiometabolic Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (J.-J.L.).ORCID 0000-0003-2536-4364
Rong-Chong HuangDepartment of Cardiology, Beijing Friendship Hospital, Capital Medical University, China (W.-H.C., Y.-T.C., Z.-J.L., R.-C.H.).ORCID 0000-0002-2607-2112

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) is a serious complication of hypertension management. However, the association between systolic blood pressure (SBP) time in target range (TTR) and the risk of AKI remains unclear.

methodsThis is a post hoc analysis of the SPRINT (Systolic Blood Pressure Intervention Trial). Participants were randomly assigned to intensive (<120 mm Hg) or standard (<140 mm Hg) SBP treatment arms. SBP TTR was defined as 110 to 130 mm Hg for the intensive arm and 120 to 140 mm Hg for the standard arm over 3 months. The primary outcome was incident AKI. The secondary outcome was the severity of AKI based on the modified Kidney Disease: Improving Global Outcomes criteria. Competing risk models were used to estimate the relationship between SBP TTR and AKI.

resultsAmong 8985 participants, 258 developed AKI (incidence, 7.62 per 1000 person-years). Each 1-SD increase in SBP TTR was associated with a 14% lower risk of AKI (hazard ratio, 0.86 [95% CI, 0.75-0.97];

conclusionsHigher SBP TTR was associated with a lower risk of AKI, independent of treatment intensity, underscoring the importance of sustained blood pressure management. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01206062.

Indexed as

Acute Kidney InjuryAntihypertensive AgentsBlood PressureHypertensionAgedBlood Pressure DeterminationFemaleHumansIncidenceMaleMiddle AgedRisk FactorsTime FactorsAntihypertensive Agentsacute kidney injuryhypertensionsystolic blood pressuretime in target range

Identifiers

PMID41064861
PMCPMC12626518

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.