Evidence map›Paper›PMID 41064860›Full record

ReviewArteriosclerosis, thrombosis, and vascular biology2025

Lung Lymphatics in Edema, Inflammation, and Thrombosis.

Chou Chou, Hasina Outtz Reed

Abstract readReview
In one paragraph

Review in Arteriosclerosis, thrombosis, and vascular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chou ChouDivision of Pulmonary and Critical Care Medicine, Department of Medicine (C.C., H.O.R.), Weill Cornell Medicine, New York, NY.ORCID 0009-0009-0495-2280
Hasina Outtz ReedDivision of Pulmonary and Critical Care Medicine, Department of Medicine (C.C., H.O.R.), Weill Cornell Medicine, New York, NY.ORCID 0000-0001-8259-9616

Funding

Multidisciplinary Approach Training in Respiratory ResearchT32HL134629 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Robert J Kaner, Heather Winona Stout Delgado · 2018 to 2026
$5.2M
Lymphatic Dysfunction in the Pathogenesis of COPDR01HL162990 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Hasina Outtz Reed · 2023 to 2026
$2.8M
Identifying Novel Roles and the Therapeutic Potential of the Thrombin Receptor Protease Activated Receptor-1 (PAR1) in Lung Lymphatic Function and Acute Respiratory Distress SyndromeR01HL179084 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Hasina Outtz Reed · 2025 to 2026
$1.5M
NHLBI NIH HHS R01 HL162990NHLBI NIH HHS R01 HL179084NHLBI NIH HHS T32 HL134629
6 · The paper itself

Abstract

The lung lymphatics are formed from lymphatic endothelial cells and play a pivotal role in lung fluid homeostasis and immune trafficking. Though blood vascular function in the lung has long been an area of active investigation, many aspects of lung lymphatic vascular function have only recently been uncovered. In this review, we will discuss our current knowledge of lung lymphatic function and how these vessels differ from lung blood vasculature in their architecture, function, and response to injury in 3 domains: edema, inflammation, and thrombosis. We will review the rich historical anatomic literature that described the lung lymphatics in great detail and elucidated foundational discoveries that continue to shape our current understanding of the lung lymphatics, even in the molecular era. We conclude by highlighting key questions for the field of lung lymphatic biology.

Indexed as

LungLymphatic VesselsPneumoniaPulmonary EdemaThrombosisAnimalsHumansInflammationLymphangiogenesisendothelium, lymphaticlung

Identifiers

PMID41064860
PMCPMC12616648

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.