Evidence map›Paper›PMID 41064837›Full record

ArticleVeterinary world2025

Phytochemical inhibition of quorum sensing and biofilm formation by

Sirijan Santajit, Techit Thavorasak, Dararat Horpet, Thida Kong-Ngoen, Uttapol Permpoon, Chul Young Kim, Tae-Gyu Nam, Nitaya Indrawattana

Abstract read
In one paragraph

Article in Veterinary world, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sirijan SantajitDepartment of Medical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, 80160, Thailand.
Techit ThavorasakDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
Dararat HorpetDepartment of Medical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, 80160, Thailand.
Thida Kong-NgoenDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
Uttapol PermpoonDepartment of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University ERICA, Ansan, Gyeonggi-do, 15588, Republic of Korea.
Chul Young KimDepartment of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University ERICA, Ansan, Gyeonggi-do, 15588, Republic of Korea.
Tae-Gyu NamDepartment of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University ERICA, Ansan, Gyeonggi-do, 15588, Republic of Korea.
Nitaya IndrawattanaBiomedical Research Incubator Unit, Department of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: Materials and Methods: Leaves of Results: GC-MS identified 30 phytoconstituents, with 5-hydroxymethyl-2-furaldehyde, 4H-pyran-4-one derivative, and eugenol as predominant compounds. Eugenol exhibited the highest binding affinity, particularly with AbaR (-6.3 kcal/mol). The extract showed significant antimicrobial activity (MIC = 7.81 mg/mL; MBC = 31.25 mg/mL) and dose-dependent inhibition of biofilm biomass (p < 0.001). FE-SEM imaging confirmed dose-responsive membrane damage and disruption of the biofilm. ADMET predictions revealed favorable oral bioavailability and low toxicity for selected compounds. Conclusion:

Indexed as

absorptionAcinetobacter baumanniibiofilm disruptiondistributioneugenolexcretiongas chromato-graphy–mass spectrometrymetabolismmolecular dockingOne HealthPaederia foetidaquorum sensing inhibitiontoxicity

Identifiers

PMID41064837
PMCPMC12501579

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.