ArticleCureus2025
Prolonged Analgesia Following Short, Pulsed Meloxicam in Generalized Osteoarthritis: A Case Report and Focused Evidence Review.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat osteoarthritis (OA), but their risks rise with cumulative exposure across the gastrointestinal, cardiovascular, and renal systems. We report a 67-year-old individual with generalized OA, no other chronic illnesses, no medication allergies, and no history of trauma, who self-administers meloxicam 15 mg once daily for seven consecutive days each month. Each monthly pulse is followed by approximately three weeks of analgesia without NSAID use between pulses, and no adverse effects have been observed. Prior evidence suggests that NSAID analgesia peaks early while minor adverse events increase after longer continuous use; this patient's real-world response supports a pragmatic, exposure-sparing approach. Although trials specifically testing fixed weekly or monthly NSAID pulses are lacking, careful patient selection and monitoring may allow short, structured courses that maintain function while minimizing cumulative risk.
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