ReviewClinical, cosmetic and investigational dentistry2025
Antibacterial Effectiveness and Periodontal Actions of Sugar-Free Chewing Gums Derived From Alcohol or Vegetables in Patients with Fixed Orthodontic Treatment: A Systematic Review.
Review in Clinical, cosmetic and investigational dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: In patients with fixed orthodontic appliances, the effectiveness of mechanical cleaning is compromised due to difficulties in accessing all areas of the mouth. Purpose: Aimed to evaluate the antimicrobial effectiveness and periodontal actions of sugar-free chewing gums in patients with fixed orthodontics through a systematic review of randomized clinical trials. Materials and Methods: A bibliographic search was conducted in digital databases for articles published up to 2024 in accordance with the PICO question. This review followed the PRISMA methodology and was registered in PROSPERO (CRD42023444472), while the Cochrane RoB 2 tool used to assess the risk of bias and GRADE employed to evaluate the certainty of evidence for each outcome. Results: Five studies were included. A significant reduction Conclusion: The different types of chewing gum significantly improved the oral health of patients with fixed orthodontics, the quality of evidence suggests that chewing gums could decrease the level of SM in saliva (4:1 xylitol and sorbitol mix or xylitol). However, the heterogeneity of the studies limits the generalization to other outcomes which highlights the need for larger and longer clinical trials to confirm their efficacy.
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