ReviewJournal of clinical and experimental dentistry2025
Malignant transformation of calcifying epithelial odontogenic tumour: A systematic review.
Review in Journal of clinical and experimental dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
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Abstract
Background: The calcifying epithelial odontogenic tumor (CEOT) is a rare benign epithelial odontogenic neoplasm. Some cases of CEOT may undergo malignant transformation, whose characteristics are still poorly known. This study aimed to perform a systematic review of CEOT cases with malignant transformation. Material and Methods: This systematic review followed the preferred reporting items for systematic reviews and meta-analyses (PRISMA) and was registered with PROSPERO (CRD42021285981). Searches for full-text articles on histopathologically confirmed CEOT cases with malignant transformation were performed in different databases (PubMed/ MEDLINE, Embase, Scopus, Web of Science, LILACS, SciELO, Google Scholar, Open Grey, and CAPES Dissertation and Thesis Catalog) without year of publication or language restrictions. A qualitative descriptive and risk of bias analysis were performed. Results: Nine cases were included, with a mean age of 59.44 (±17.07) years and a slightly higher frequency in males (55.6%). The mandible (88.9%) was the most affected site, with predominance of the mixed imaging pattern (77.8%). Histopathologically, the clear cell variant, intense mitotic activity, presence of cellular atypia, and high Ki-67 immunoexpression were the predominant findings. Isolated surgery (44.4%) was the most common treatment and recurrence of CEOT before malignant transformation was observed in five cases (55.6%). CEOT with malignant transformation recurred in three cases (33.3%). Most cases had a positive outcome (77.8%), with remission of the disease. Conclusions: This systematic review determined the clinicopathological profile of histopathologically confirmed cases of CEOT with malignant transformation and synthesized some characteristics that can assist in the diagnosis and appropriate therapeutic approach of this rare neoplasm.
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