Evidence map›Paper›PMID 41064771›Full record

ReviewJournal of clinical and experimental dentistry2025

Microbiological and Pharmacological Aspects Involved in Dentin-Pulp Complex Regeneration: A Scoping Review.

Isabela Giraldo-Badillo, Eliana Pineda-Vélez, Belfran A Carbonell-Medina, Carlos M Ardila

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical and experimental dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Isabela Giraldo-BadilloMaster's Program in Microbiology. Genetics, Regeneration, and Cancer Research Group. School of Microbiology, University of Antioquia, UdeA, Medellín, Colombia.
Eliana Pineda-VélezEndodontist. Master's in Epidemiology. Basic Studies Department, Faculty of Dentistry, University of Antioquia, UdeA. Genetics, Regeneration, and Cancer Research Group. University of Antioquia, UdeA. Medellín, Colombia.
Belfran A Carbonell-MedinaPh.D. in Biological Sciences. Basic Studies Department, Faculty of Dentistry, University of Antioquia, UdeA. Genetics, Regeneration, and Cancer Research Group. University of Antioquia, UdeA. Medellín, Colombia.
Carlos M ArdilaDepartment of Periodontics, Saveetha Dental College, Saveetha Institute of Medical and technology sciences, SIMATS, Saveetha. University, Chennai, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The regeneration of the dentin-pulp complex represents a pivotal challenge in endodontics, requiring a delicate balance between microbial eradication and tissue repair. This scoping review, conducted in accordance with PRISMA-ScR guidelines, synthesizes current evidence on microbiological and pharmacological factors influencing regenerative outcomes. Material and Methods: A systematic search of PubMed, Scopus, Web of Science, and Cochrane Library identified 242 studies, with 15 meeting inclusion criteria after screening. Results: The review highlights the dominance of anaerobic biofilm-forming pathogens (Enterococcus faecalis, Conclusions: Future directions emphasize microbiome-targeted therapies, advanced biomaterials, and personalized approaches leveraging metagenomics. This review underscores the imperative to integrate selective antimicrobial strategies with regenerative biology to advance endodontic outcomes.

Identifiers

PMID41064771
PMCPMC12502716

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.