Chewing Gum as a Delivery System for Cannabidiol: A Commentary.

Background: Despite significant gaps in the research literature, the integration of cannabidiols into chewing gum as a drug delivery system is a novel and promising approach for various cannabinoid therapeutic applications. Chewing gum offers a unique delivery mechanism that may promote both local and systemic effects through the oral mucosa, enhancing the bioavailability and efficacy of cannabinoid medications. Summary: This commentary explores and delves into the potential of cannabinoid-infused chewing gum, highlighting its putative benefits for managing an array of conditions, including oral health, anxiety, and pain. The therapeutic potential of cannabinoids is explored in the context of their anti-inflammatory, antimicrobial, analgesic, and anxiolytic properties that may be especially impactful in the oral cavity and at the oral-pharyngeal mucosa. Additionally, we reviewed the advantages of using chewing gum for discrete self-medication and rapid onset of salutary effects. Key Messages: Despite a long-standing widespread history of chewing gum use in general, there is sparse experience and even less clinical research on the effects and possible clinical value of incorporating cannabidiol or any other cannabinoid in a chewing gum product. Despite promising reports, research gaps remain, particularly in understanding the absorption mechanisms, dosing precision, and long-term safety of cannabinoid-based chewing gum. Addressing these challenges will position cannabinoid-infused chewing gum as a versatile and effective drug delivery system for a range of health conditions.