Evidence map›Paper›PMID 41064667›Full record

ArticleThe Pan African medical journal2025

Thyroid-associated orbitopathy following COVID-19: a case report.

Sabrine Mekni, Hager Khiari, Manel Mekni, Jihene Sayadi, Sawsen Essayeh, Rihab Laamouri, Imen Rojbi, Ibtissem Ben Nacef

Abstract readCase Reports
In one paragraph

Article in The Pan African medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sabrine MekniDepartment of Endocrinology, Charles Nicolle Hospital, Tunis, Tunisia.
Hager KhiariDepartment of Endocrinology, Charles Nicolle Hospital, Tunis, Tunisia.
Manel MekniDepartment of Ophthalmology, Hedi Raies Hospital, Tunis, Tunisia.
Jihene SayadiDepartment of Ophthalmology, Hedi Raies Hospital, Tunis, Tunisia.
Sawsen EssayehDepartment of Endocrinology, Charles Nicolle Hospital, Tunis, Tunisia.
Rihab LaamouriDepartment of Endocrinology, Charles Nicolle Hospital, Tunis, Tunisia.
Imen RojbiDepartment of Endocrinology, Charles Nicolle Hospital, Tunis, Tunisia.
Ibtissem Ben NacefDepartment of Endocrinology, Charles Nicolle Hospital, Tunis, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies have shown a link between COVID-19 vaccination and the development of Graves' disease (GD) and Graves' orbitopathy (GO). However, to the best of our knowledge, this is only the second reported case of clinically overt GO following COVID-19 infection. Herein, we report a 48-year-old female patient who was initially treated in 2017 with radioactive iodine therapy for a toxic thyroid adenoma. In 2021, the patient was diagnosed with COVID-19. Ten days later, she developed bilateral, active, moderate-to-severe GO, accompanied by elevated thyrotropin receptor antibody (TRAb) levels. She was treated with intravenous methylprednisolone followed by oral prednisone and later underwent orbital decompression surgery, followed by strabismus surgery due to worsening diplopia. No complications occurred postoperatively, and her symptoms improved significantly. This case contributes to the literature by suggesting a potential association between COVID-19 infection and the onset of autoimmune diseases, including GO.

Indexed as

COVID-19Graves OphthalmopathyAdenomaAutoantibodiesDecompression, SurgicalDiplopiaFemaleHumansMethylprednisoloneMiddle AgedPrednisoneReceptors, ThyrotropinThyroid NeoplasmsAutoantibodiesMethylprednisolonePrednisoneReceptors, Thyrotropincase reportGraves' diseaseGraves' ophthalmopathyiodine radioisotopesSARS-CoV-2

Identifiers

PMID41064667
PMCPMC12500901

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.