Evidence map›Paper›PMID 41064613›Full record

ArticleClinical case reports2025

Pediatric Moyamoya Disease in Nepal and Challenges in a Resource-Limited Setting: A Case Report.

Kapil Khanal, Sunil Dhungana, Bindu Gyawali, Rishab Khanal, Binit Bajracharya, Nishant Neupane, Nijan Sharma, Kailash Mani Pokhrel, Manish Acharya, Shreya Sinha

Abstract read
In one paragraph

Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kapil KhanalMaharajgunj Medical Campus (MMC), Institute of Medicine (IOM) Tribhuvan University (TU) Kathmandu Nepal.ORCID https://orcid.org/0009-0006-0183-261X
Sunil DhunganaDepartment of Pediatric Medicine Maharajgunj Medical Campus (MMC), Institute of Medicine (IOM), Tribhuvan University (TU) Kathmandu Nepal.
Bindu GyawaliDepartment of Pediatric Medicine Maharajgunj Medical Campus (MMC), Institute of Medicine (IOM), Tribhuvan University (TU) Kathmandu Nepal.
Rishab KhanalDepartment of Pediatric Medicine Maharajgunj Medical Campus (MMC), Institute of Medicine (IOM), Tribhuvan University (TU) Kathmandu Nepal.
Binit BajracharyaDepartment of Pediatric Medicine Maharajgunj Medical Campus (MMC), Institute of Medicine (IOM), Tribhuvan University (TU) Kathmandu Nepal.
Nishant NeupaneMaharajgunj Medical Campus (MMC), Institute of Medicine (IOM) Tribhuvan University (TU) Kathmandu Nepal.ORCID https://orcid.org/0009-0007-6266-9745
Nijan SharmaMaharajgunj Medical Campus (MMC), Institute of Medicine (IOM) Tribhuvan University (TU) Kathmandu Nepal.ORCID https://orcid.org/0009-0004-4611-3032
Kailash Mani PokhrelMaharajgunj Medical Campus (MMC), Institute of Medicine (IOM) Tribhuvan University (TU) Kathmandu Nepal.ORCID https://orcid.org/0000-0002-4645-5321
Manish AcharyaDepartment of Emergency Medicine Maharajgunj Medical Campus (MMC), Institute of Medicine (IOM), Tribhuvan University (TU) Kathmandu Nepal.ORCID https://orcid.org/0009-0009-0583-1448
Shreya SinhaMaharajgunj Medical Campus (MMC), Institute of Medicine (IOM) Tribhuvan University (TU) Kathmandu Nepal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Moyamoya disease (MMD) is a rare progressive cerebrovascular disorder characterized by stenosis of the terminal internal carotid arteries with fragile collateral vessel formation. It is common in East Asia but underreported in Nepal. Pediatric cases typically present with ischemic symptoms such as transient ischemic attacks, stroke, or seizures. We report a 7-year-old Nepali boy with 11 days of fever followed by recurrent tonic-clonic seizures, progressive right-sided weakness, and impaired fine motor function. Examination showed right hemiparesis with an upgoing plantar reflex. MRI and MR angiography revealed multiple acute infarcts with supraclinoid internal carotid artery stenosis and extensive collateral vessels, confirming MMD. Cerebrospinal fluid and autoimmune workup were unremarkable. The child was managed conservatively with aspirin and levetiracetam, leading to partial recovery. Surgery was deferred due to financial limitations and initial improvement. This case underscores the importance of considering MMD in pediatric strokes in non-endemic regions. In resource-limited settings like Nepal, conservative treatment offers symptomatic relief, but long-term follow-up is essential to monitor progression and surgical needs.

Indexed as

antiplatelet therapycerebrovascular disorderconservative managementmoyamoya diseasepediatric stroketransient ischemic attack

Identifiers

PMID41064613
PMCPMC12500407

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.