ArticleFrontiers in bioengineering and biotechnology2025
Sonodynamic and magnetic targeting platelet-membrane biomimetic platform for glioblastoma therapy.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Due to the presence of the blood-brain barrier, the efficacy of chemotherapy for glioblastoma has remained suboptimal. Even drugs capable of crossing the BBB, such as temozolomide, exhibit limited therapeutic outcomes owing to insufficient targeting. Methods: Here, we developed a platelet membrane-hybridized biomimetic microbubble by loading superparamagnetic iron oxide and temozolomide-embedded polymers, constructing an ultrasound-controlled platelet membrane-inspired magnetic targeting drug delivery platform (ST-PM). Extensive Results: The results demonstrated that ST-PM significantly enhanced microbubble stability Conclusion: The platelet membrane enhances the stability of drug-loaded microbubbles, facilitating targeted drug accumulation at the lesion site. These findings propose a novel treatment strategy with clinical translation potential for glioblastoma management.
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