Evidence map›Paper›PMID 41064495›Full record

ArticleJournal of inflammation research2025

Isolated Central Nervous System FHL3 in an Asian Pediatric Patient: A Case Report and Literature Review.

Zhanwei Zhang, Haolin Duan, Ciliu Zhang, Fang He, Fei Yin, Lifen Yang, Jing Peng

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhanwei ZhangDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, People's Republic of China.
Haolin DuanDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, People's Republic of China.
Ciliu ZhangDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, People's Republic of China.
Fang HeDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, People's Republic of China.
Fei YinDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, People's Republic of China.
Lifen YangDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, People's Republic of China.ORCID 0000-0003-2400-9539
Jing PengDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, People's Republic of China.ORCID 0000-0002-7752-6962

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Familial hemophagocytic lymphohistiocytosis (FHL) is a genetic inflammatory response syndrome involving many organs. Central nervous system (CNS)-isolated FHL is a rare, neuroinflammatory condition. Here, we report a case of CNS-isolated FHL3. Brain magnetic resonance imaging (MRI) showed CNS lesions mimicking chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids and multiple sclerosis. Whole-exome sequencing (WES) demonstrated likely pathogenic, parentally inherited homozygous variants of

Indexed as

allogeneic hematopoietic stem cell transplantationcentral nervous systemchronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroidsfamilial hemophagocytic lymphohistiocytosisUNC13D

Identifiers

PMID41064495
PMCPMC12500473

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.