ArticleJournal of inflammation research2025
Comprehensive Analysis and Experimental Validation of Immune-Related Biomarkers and Immune Microenvironment in Diabetic Nephropathy.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The molecular mechanism of diabetic nephropathy (DN) is still not fully understood. There is ample evidence that the immune system plays a crucial role in the progression of DN. Further exploration of immune-related genes (IRGs) for DN diagnosis is therefore of significant clinical value. Methods: Gene expression data from DN patients were obtained from the GEO database, and a weighted gene co-expression network analysis (WGCNA) was constructed. The overlapping IRGs derived by the least absolute shrinkage and selection operator (LASSO) and recursive feature elimination (RF) algorithms were identified as DN diagnostic biomarkers. A nomogram model was established to evaluate the diagnostic ability of feature biomarkers. The expression levels of the screened IRGs were validated in vitro using qRT-PCR. Type 2 diabetes mellitus (T2DM) mouse model with DN was also established to confirm the consistency with bioinformatic predictions. Results: Three IRG-related DN characteristic diagnostic biomarkers ( Conclusion: Our findings nominate
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