ArticleBioImpacts : BI2025
Investigate the co-culture effects of BM-mesenchymal stem cells on the promotion of apoptotic pathways of CD34
Article in BioImpacts : BI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Introduction: The potential clinical application of mesenchymal stem cells (MSCs) in cell-based treatment makes them particularly interesting. The use of MSC-engaged therapies in cancer treatment is becoming more and more promising. Although the specifics of their activity have not yet been conclusively established, a variety of growth factors released by these cells are known to provide such multifunctional qualities. Methods: Through the measurement of cytokine levels, Annexin-V, and possible signaling pathways linked to apoptosis, we have assessed the impact of MSCs on CD34 Results: Co-culture conditions were observed to promote early and late apoptosis, although this increase just was statistically significant in late apoptosis. The co-cultured conditioned media clearly showed a large amount of IL-2, but there was an insignificant rise in IL-4. Also, MSCs significantly increased the protein expression of P16, P21, and p-P38 and significantly decreased C-Myc, and TERC. Conclusion: It can be concluded that the mentioned effects of IL-2 cytokine released from MSCs on CD34
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