Evidence map›Paper›PMID 41064363›Full record

ReviewFrontiers in endocrinology2025

Mechanisms of follicular atresia: focus on apoptosis, autophagy, and ferroptosis.

Tongqing Zhang, Menghan Lin, Chuangui Wang, Jiaqi Zhou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  12. Relationship between different modes of death and premature ovarian insufficiency: a literature review.Apoptosis : an international journal on programmed cell death · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tongqing ZhangSchool of Life Sciences and Medicine, Shandong University of Technology, Zibo, China.
Menghan LinSchool of Life Sciences and Medicine, Shandong University of Technology, Zibo, China.
Chuangui WangSchool of Life Sciences and Medicine, Shandong University of Technology, Zibo, China.
Jiaqi ZhouSchool of Life Sciences and Medicine, Shandong University of Technology, Zibo, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Follicular atresia is a critical physiological process that ensures the selection of high-quality oocytes by eliminating non-viable follicles. In women, 99.9% of follicles undergo atresia naturally, the premature or dysregulated atresia follicle can lead to pathological conditions such as polycystic ovary syndrome (PCOS) and premature ovarian failure (POF). Recent studies highlight the roles of apoptosis, autophagy, and ferroptosis in regulating follicular atresia. This review integrates molecular mechanisms of programmed cell death with follicular dynamics, emphasizing how aberrant atresia disrupts reproductive health. We discuss therapeutic strategies targeting these pathways to mitigate pathological atresia, offering insights into preserving ovarian reserve and improving fertility outcomes.

Indexed as

ApoptosisAutophagyFerroptosisFollicular AtresiaOvarian FollicleAnimalsFemaleHumansPolycystic Ovary Syndromeapoptosisautophagyferroptosisfollicle atresiapremature ovarian failure

Identifiers

PMID41064363
PMCPMC12500450

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.