Evidence map›Paper›PMID 41064333›Full record

ReviewJournal of multidisciplinary healthcare2025

Acupuncture on Post-Stroke Cognitive Impairment: A Systematic Review of Neuroimaging Studies.

Shiqi Yang, Qiongnan Bao, Wanqi Zhong, Kexin Wu, Xinyue Zhang, Jin Yao, Ziwen Chen, Ping Xu, Zihan Yin, Fanrong Liang

Abstract readReview
In one paragraph

Review in Journal of multidisciplinary healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shiqi Yang *School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.ORCID 0009-0005-1409-556X
Qiongnan Bao *School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Wanqi ZhongSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Kexin WuSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Xinyue ZhangSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Jin YaoSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Ziwen ChenSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.ORCID 0000-0001-8287-2723
Ping XuSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Zihan YinSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Fanrong LiangSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.ORCID 0000-0001-8518-9268

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Post-stroke cognitive impairment (PSCI) is a severe central nervous system disorder for which acupuncture demonstrates therapeutic efficacy. Various neuroimaging studies have indicated that acupuncture may exert its effects through modulating central mechanisms. However, owing to the current lack of a systematic summary, this study aimed to integrate the existing evidence. Methods: Two independent reviewers conducted a search across eight databases and other sources, identifying potential neuroimaging trials on acupuncture for PSCI, spanning from the inception of the databases to August 25, 2024. Eligible studies were screened based on predefined inclusion and exclusion criteria, and their methodological quality was assessed. Results: Twelve studies, including 671 participants, utilized manual acupuncture (n = 10), electroacupuncture (n = 1), or a combination of both (n = 1). Neuroimaging tools comprised functional magnetic resonance imaging (n = 7), electroencephalography (n = 2), magnetic resonance spectroscopy (n = 2), and functional near-infrared spectroscopy (n = 1). All studies consistently reported positive effects of acupuncture on patients suffering from PSCI. Changes in brain structure and function resulting from acupuncture are commonly observed in the cingulate cortex, parahippocampal gyrus, prefrontal cortex, and fusiform gyrus. Acupuncture appears to modulate cognition-related networks, including the default mode, central executive, frontoparietal, and salience networks, thereby influencing PSCI. Conclusion: The therapeutic effects of acupuncture on PSCI may be mediated through the regulation of cognition-related brain networks. Yet, these studies remain at an exploratory stage, necessitating a combination of multiple imaging techniques and large, strictly designed multicenter RCTs to validate the neuroimaging findings.

Indexed as

acupuncturemechanismneuroimagingpost-stroke cognitive impairmentsystematic review

Identifiers

PMID41064333
PMCPMC12503189

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.