ArticleCase reports in dermatology
Histologic Clearance of a Giant Cutaneous Squamous Cell Carcinoma with Imiquimod 5% Cream: A Case Report.
Article in Case reports in dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Introduction: Cutaneous squamous cell carcinoma (cSCC) is one of the most common skin cancers, with an increasing incidence worldwide. Chronic sun exposure is a major risk factor and lesions are usually observed on sun-exposed areas such as the face, neck, scalp, and hands. Imiquimod cream, an immune response modifier, has shown promising results in the management of selected cases of cSCC. Case Report: A 70-year-old, Filipino male presented with 3-year history of a slow growing erythematous plaque on the abdomen. Physical examination revealed a solitary, well-defined, erythematous plaque measuring 5 cm on the left lower quadrant of the abdomen. Histopathologic examination confirmed cSCC. The patient declined surgery and opted for topical treatment with imiquimod 5% cream, applied over 24 weeks for a total of 104 applications. Serial biopsies taken at multiple follow-up points and anatomic sites confirmed complete histologic clearance. Conclusion: This case highlights one of the few documented instances of histologic cure in a >5 cm cSCC treated solely with imiquimod cream. It underscores the potential of imiquimod as a nonsurgical alternative and expands current treatment for patients who may not be suitable candidates for conventional surgical excision.
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