ReviewFrontiers in nutrition2025
Interaction between Notch signaling pathway and bioactive compounds and its intervention on cancer.
Review in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Antioxidants as a Link Between Diabetes and Potential Plant-Based Therapies.Antioxidants (Basel, Switzerland) · 2026Review
- Genetics and Molecular Mechanisms in Oral Squamous Cell Carcinoma: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Stem Cell-Derived Organoids for Cancer Therapy: Precision Medicine and Drug Selection.International journal of molecular sciences · 2026Review
- SIRT1 induces FOXO1/autophagy/NCOA4-induced ferroptosis and accelerates the progression of cerebral infarction by inhibiting the E2F1/NOTCH-1/YAP signaling pathway.Scientific reports · 2026Article
- Quercetin induces ferroptosis in ovarian cancer through regulating HSPB1/Notch1 pathway.Journal of ovarian research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Notch signaling pathway is pivotal in cancer regulation, with its effects varying based on activation degree, tissue origin, and microenvironment. The dual role of Notch signaling is significant. It can promote or inhibit cancer progression depending on the context. This duality emphasizes the importance of nuanced therapeutic approaches. Recent research highlights natural bioactive compounds as modulators of Notch signaling, providing innovative insights for cancer prevention and therapy. This review explores the structural and functional mechanisms of Notch signaling in carcinogenesis and examines how natural compounds influence its activity, offering a foundation for targeted treatments. Bioactive compounds, such as flavonoids, non-flavonoids polyphenols, and terpenoids, show potential in modulating Notch signaling with low toxicity and multi-target effects. Compounds like resveratrol, curcumin, and EGCG inhibit key nodes in Notch signaling, reducing cancer cell proliferation and inflammation. Despite its promise, targeting Notch signaling poses challenges due to its complexity and variability across different cancers. Future research should focus on understanding the tissue-specific effects of Notch signaling, optimizing bioactive compound structures, and integrating basic and clinical studies to develop precision therapies. This review underscores the intricate role of Notch signaling in cancer and the transformative potential of bioactive compounds in therapeutic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.