Evidence map›Paper›PMID 41064110›Full record

ArticleInternational journal of nanomedicine2025

Bioinspired RGD-Functionalized Gold Nanoparticles for Integrin-Driven Interaction with Melanoma Cells.

Annarita Del Gatto, Patrizia Di Pietro, Michele Saviano, Marianna Flora Tomasello, Giuseppe Pappalardo, Rony Snyders, Giuseppe Forte, Cristina Satriano, Laura Zaccaro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Annarita Del Gatto *Institute of Biostructures and Bioimaging (IBB), Naples, Italy.
Patrizia Di Pietro *NanoHybrid Biointerfaces Laboratory (NHBIL), Department of Chemical Sciences, University of Catania, Catania, Italy.
Michele SavianoInteruniversity Research Centre on Bioactive Peptides (CIRPeB) "carlo Pedone", University of Naples, Naples, Italy.
Marianna Flora TomaselloInstitute of Crystallography (IC), Bari, Italy.ORCID 0000-0001-6745-2181
Giuseppe PappalardoInstitute of Crystallography (IC), Bari, Italy.ORCID 0000-0001-7328-3492
Rony SnydersPlasma-Surface Interaction Chemistry, University of Mons, Mons, Belgium.ORCID 0000-0001-8164-346X
Giuseppe ForteDepartment of Drug and Health Sciences, University of Catania, Catania, Italy.
Cristina SatrianoNanoHybrid Biointerfaces Laboratory (NHBIL), Department of Chemical Sciences, University of Catania, Catania, Italy.ORCID 0000-0001-5348-5863
Laura ZaccaroInstitute of Biostructures and Bioimaging (IBB), Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: In this study, we investigated the physicochemical properties, biofunctionalization and internalization mechanisms of peptide-functionalized gold nanoparticles (GNPs), with a particular focus on a cyclic a Methods: The characterisation of the GNPs and their biofunctionalised counterparts (b-GNPs) was carried out by a series of techniques including dynamic light scattering (DLS), zeta potential (ζ) measurements, UV-visible (UV-vis) spectroscopy, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and theoretical modelling. Cellular uptake experiments were performed in human adenocarcinoma (HeLa, a Results: The physicochemical characterisation confirmed the successful functionalisation of GNPs with the bioinspired multifunctional cRGD-GCt-FITC moiety. Detailed analysis of the nano-bio interface revealed distinct chemical states and evidence of charge transfer effects between the GNPs surface and the RGD-containing peptide. Cellular studies demonstrated selective uptake and preferential accumulation of b-GNPs in a Conclusion: This work provides new understanding of biomimetic gold nanoparticles and highlights their potential in tumour selective strategies, particularly for integring-targeted theranostics, while addressing toxicity and targeting limitations of current RGD- and gold nanoparticle-based nanomedicine.

Indexed as

GoldIntegrin alphaVbeta3MelanomaMetal NanoparticlesOligopeptidesCell Line, TumorFluorescein-5-isothiocyanateHeLa CellsHumansarginyl-glycyl-aspartic acidFluorescein-5-isothiocyanateGoldIntegrin alphaVbeta3Oligopeptidescancer nanomedicinepeptideplasmonic nanoparticlestargetingtheranostics

Identifiers

PMID41064110
PMCPMC12502969

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.