Evidence map›Paper›PMID 41064019›Full record

ArticleJournal of advanced periodontology & implant dentistry2025

Impact of animal source on biocompatibility of bone xenografts: A comparative animal study.

Ardeshir Lafzi, Reza Amid, Mahdi Kadkhodazadeh, Anahita Moscowchi, Javad Mehrani, Nima Ahmadi, Amirali Karimi Vasigh

Abstract read
In one paragraph

Article in Journal of advanced periodontology & implant dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ardeshir LafziDental Research Center, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0003-4866-2890
Reza AmidDental Research Center, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mahdi KadkhodazadehDental Research Center, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Anahita MoscowchiDental Research Center, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0003-1327-5014
Javad MehraniDepartment of Periodontics, Faculty of Dentistry and Tissue Engineering, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Nima AhmadiDepartment of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Amirali Karimi VasighDepartment of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-2445-4424

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The study aimed to compare the results of cytotoxicity and in vivo irritation and sensitization tests of a new antler-derived bone substitute with those of a bovine-derived xenograft. Methods: This study included an in vitro cytotoxicity test based on ISO 10993-5 standard. Additionally, in vivo irritation and sensitization tests were carried out according to ISO 10993-10 standard protocol. Results: The cytotoxicity test showed a viability of 99.46±1.09% for the antler-derived bone substitute and 98.42±1.84% for the bovine xenograft ( Conclusion: Both the antler-derived and bovine xenografts were found to be non-toxic, non-irritating, and non-sensitizing. Further studies should be conducted on other essential laboratory tests and animal and clinical studies.

Indexed as

AntlerBone substituteCytotoxicity testIrritation testingSensitization testing

Identifiers

PMID41064019
PMCPMC12501480

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.