ArticleFrontiers in immunology2025
Predictive factors and outcomes of immune-related adverse events in Chinese patients treated with immune checkpoint inhibitors: a real-world retrospective study.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Immune checkpoint inhibitor-induced bullous pemphigoid: a systematic review of clinical characteristics and outcomes based on case reports.Frontiers in immunology · 2026Pooled it
- Review
- Impact on survival of severe immuno-related adverse events in deficient mismatch repair/microsatellite instable-high digestive cancers treated with immunotherapy.Journal for immunotherapy of cancer · 2026Observational
- Characteristics and risk factors of immune-related adverse events in patients receiving immune checkpoint inhibitor combination therapy.Frontiers in oncology · 2026Article
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3 authors.
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Abstract
Background: The widespread clinical application of immune checkpoint inhibitors (ICIs) has brought immune-related adverse events (irAEs) to the forefront of oncology management. However, systematic investigations focusing on the efficacy and irAE profiles of ICIs locally developed in China (Chinese ICIs) in real-world settings remain limited. This study aimed to explore predictive factors and outcomes of irAEs in patients predominantly treated with Chinese ICIs. Methods: In this single-center retrospective study, 206 patients with solid tumors treated with ICIs between 2020 and 2024 were included, with 87.9% receiving Chinese ICIs. Multivariate regression analyses were conducted to identify predictors of irAEs and factors associated with progression-free survival (PFS). Clinical characteristics, inflammatory biomarkers, cytokine levels, and cardiac function parameters were comprehensively evaluated. Results: Younger age (p=0.04) and the brain metastases (p=0.03) were associated with a higher incidence of irAEs. Organ-specific irAEs showed distinct predictors: hepatitis with younger age, hepatitis B virus (HBV) infection, hepatic malignancy, multisystem irAEs, and elevated IL-10; myocarditis with multisystem irAEs, systemic inflammation markers (white blood cell count, WBC; neutrophil-to-lymphocyte ratio, NLR; systemic immune-inflammation index, SII; systemic inflammation response index, SIRI), and cardiac function indicators (left ventricular ejection fraction, LVEF; QRS duration); thyroiditis with multisystem irAEs and reduced IL-6; while pneumonitis with elevated platelet count (PLT) and IL-6. The type of irAEs was not associated with PFS. Conclusions: Younger age and brain metastases were associated with a higher incidence of irAEs. Organ-specific irAEs were characterized by distinct sets of clinical and laboratory predictors. Inflammatory markers correlated with poorer PFS. The type of irAEs was not associated with PFS. Chinese ICIs were not independently associated with an increased risk of specific organ toxicities.
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