ReviewFrontiers in immunology2025
Research progress of macrophage ferroptosis in inflammatory bowel disease and inflammation-cancer transformation.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Ferroptosis in cancer: molecular mechanisms, tumour microenvironment, therapeutic resistance, and clinical translation.Journal of the Egyptian National Cancer Institute · 2026Review
- Iron Metabolism in the Colorectal Tumor Microenvironment: Current Evidence and Clinical Implications.Diagnostics (Basel, Switzerland) · 2026Review
- Ferroptosis in colorectal cancer: Molecular mechanisms and regulatory crosstalk with therapeutic prospects (Review).Oncology reports · 2026Review
- Monocyte-Derived Macrophage Ferroptosis Amplifies Cholangitis in Primary Biliary Cholangitis via a Calpain/ACSL4 Axis.Biomedicines · 2026Article
- Review
- Article
- Sodium Butyrate Alleviates IBD by Modulating SIRT1-Involved Ferroptosis and Inhibition of Macrophage Ferroptosis.Nutrients · 2026Article
- Novel insights of ferroptosis in atherosclerosis progression.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathophysiology of inflammatory bowel disease (IBD), a chronic intestinal inflammatory disease, is tightly associated with immunological dysregulation, intestinal flora abnormalities, and intestinal epithelial cell destruction. Ferroptosis-a non-apoptotic cell death form that differs from the standard apoptotic mode-plays a significant regulatory role in the development of IBD through iron-dependent lipid peroxide accumulation. Iron serves as a critical component for maintaining the normal function of macrophages. Macrophages have been demonstrated to play multifaceted roles in the pathogenesis and progression of inflammatory bowel disease. The iron metabolism within macrophages may potentially influence the development of IBD and colitis-associated cancer. This paper summarizes the present research on ferroptosis and macrophages and their related molecular mechanisms. It also discusses the interactive function of macrophage ferroptosis in the development of IBD and inflammatory-cancer transformation. The development of new theoretical foundations and intervention techniques for the prevention and treatment of IBD and colitis-associated colorectal cancer will be facilitated by the growth of this research area.
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Registered trials
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