Evidence map›Paper›PMID 41063987›Full record

Observational studyFrontiers in immunology2025

The amphiregulin- epidermal growth factor receptor axis as a therapeutic target in sepsis.

Rebecca Walsh, Timothy Arthur Chandos Snow, Alexandra Z Martinez, David Brealey, Mervyn Singer, Abhishek Das, Nishkantha Arulkumaran, University College London Hospitals Critical Care Research Team

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Peri-Operative Antimicrobial Prophylaxis Modulates CD4Antibiotics (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rebecca Walsh *Bloomsbury Institute of Intensive Care Medicine, University College London, London, United Kingdom.
Timothy Arthur Chandos Snow *Bloomsbury Institute of Intensive Care Medicine, University College London, London, United Kingdom.
Alexandra Z MartinezBloomsbury Institute of Intensive Care Medicine, University College London, London, United Kingdom.
David BrealeyBloomsbury Institute of Intensive Care Medicine, University College London, London, United Kingdom.
Mervyn SingerBloomsbury Institute of Intensive Care Medicine, University College London, London, United Kingdom.
Abhishek Das *NIHR UCLH Biomedical Research Centre, London, United Kingdom.
Nishkantha Arulkumaran *Bloomsbury Institute of Intensive Care Medicine, University College London, London, United Kingdom.
University College London Hospitals Critical Care Research Team

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Epidermal Growth Factor Receptor (EGFR) and its ligand, amphiregulin (AREG) are critical for epithelial cell proliferation but their important role in inflammation and infection is increasingly described. We recently discovered that the EGFR ligand, amphiregulin, could identify a cohort of infants with sepsis, even when CRP was low, identifying it as a potentially adjunctive biomarker for early infection. Its role in adult sepsis however, has yet to be delineated. We conducted a prospective observational study of 42 critically ill septic adult patients on the Intensive Care Unit, comparing serum amphiregulin levels and the frequencies of EGFR-expressing myeloid and lymphoid cells (using spectral flow cytometry) in sepsis survivors and non-survivors, and 20 healthy volunteers. We demonstrate, for the first time, the strong association between serum amphiregulin and in-hospital mortality (AUROC = 0.87). Moreover, we demonstrate that a higher frequency of circulating CD4

Indexed as

AmphiregulinErbB ReceptorsSepsisAdultAgedBiomarkersCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleHospital MortalityHumansMaleMiddle AgedProspective StudiesSignal TransductionAmphiregulinAREG protein, humanBiomarkersEGFR protein, humanErbB Receptorsamphiregulinepidermal growth factor receptorintensive care unitlymphocytemonocytesepsis

Identifiers

PMID41063987
PMCPMC12500437

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.