Evidence map›Paper›PMID 41063983›Full record

ArticleFrontiers in immunology2025

MyD88 orchestrates fatty acid metabolism in tumor-associated macrophages and non-alcoholic fatty liver disease-related hepatocarcinogenesis.

Haiqiang Chen, Xuanxuan Yan, Zuyin Li, Zhenzhong Deng, Jianchun Gu, Fanxin Zeng, Zhao Li, Jinhua Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haiqiang Chen *The College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing, China.
Xuanxuan Yan *The College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing, China.
Zuyin LiDepartment of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, China.
Zhenzhong DengDepartment of Oncology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Jianchun GuDepartment of Oncology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Fanxin ZengDepartment of Clinical Research Center, Dazhou Central Hospital, Dazhou, Sichuan, China.
Zhao LiDepartment of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, China.
Jinhua ZhangThe College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Non-alcoholic fatty liver disease (NAFLD) is a growing cause of cirrhosis and hepatocellular carcinoma (HCC). Toll-like receptors (TLRs) and their adapter protein, myeloid differentiation factor 88 (MyD88), are activated in NAFLD and contribute to its development. However, the specific role of MyD88 in myeloid cells that regulate NAFLD-associated hepatocarcinogenesis remains unknown. Methods: We used a diethylnitrosamine/high-fat diet-induced HCC mouse model with selective deletion of MyD88 from myeloid cells to investigate NAFLD-HCC, and we evaluated the development of NAFLD-HCC histologically and genetically. Results: Myeloid cell MyD88-deficient (Lyz Discussion: MyD88 in macrophages has a promotional role in NAFLD-associated HCC. MyD88 promotes macrophage M2 polarization, which enhances the progression of NAFLD to HCC by activating the SREBP1/STAT6 pathway. MyD88 in macrophages may be a potential therapeutic and/or preventive target for NAFLD-associated HCC.

Indexed as

Carcinoma, HepatocellularFatty AcidsLiver NeoplasmsMyeloid Differentiation Factor 88Non-alcoholic Fatty Liver DiseaseTumor-Associated MacrophagesAnimalsCarcinogenesisDiet, High-FatDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionFatty AcidsMyd88 protein, mouseMyeloid Differentiation Factor 88STAT6 Transcription FactorSterol Regulatory Element Binding Protein 1HCCmacrophageMyD88NAFLDSREBP1

Identifiers

PMID41063983
PMCPMC12500666

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.