Trial reportFrontiers in immunology2025
Comparative analysis of neutralization assays performed using live SARS-CoV-2 virus and pseudovirus to assess immunogenicity of a bivalent SARS-CoV-2 protein vaccine in humans.
Trial report in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
9 authors.
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Abstract
Objectives: The rapid emergence of SARS-CoV-2 prompted accelerated vaccine development, with neutralization assays serving as essential tools to evaluate vaccine-induced immune responses. Methods: A Results: We analyzed 324 samples for Alpha and Beta variants and 505 for Delta. Compared with LVNA, the sensitivity and specificity of PVNA were over 90% across all variants, with accuracy rates of 98.8% for Alpha, 99.1% for Beta, and 94.3% for Delta. The Pearson correlation between PVNA and LVNA was strong for Alpha (CORR = 0.9614), Beta (CORR = 0.9517), and Delta (CORR = 0.9072). Bland-Altman plots and Kernel density plots indicated good agreement between PVNA and LVNA. Conclusions: Our findings demonstrate a strong correlation between PVNA and LVNA results, supporting PVNA as a safe, scalable, and reliable surrogate for LVNA in evaluating vaccine immunogenicity.
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