ArticleFrontiers in cellular neuroscience2025
Lactate infusion increases circulating pro-brain-derived neurotrophic factor levels in humans.
Article in Frontiers in cellular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- High-intensity interval training differentially modulates acute BDNF and cognitive responses in young adult males: a randomized crossover trial.Scientific reports · 2026Trial
- Physiological predictors of exercise-induced increases in circulating BDNF isoforms and net cerebral lactate exchange in healthy adults.Frontiers in physiology · 2026Article
- Lactate infusion increases circulating pro-brain-derived neurotrophic factor levels in humans.Frontiers in cellular neuroscience · 2025Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Brain-derived neurotrophic factor (BDNF) is a key mediator of neuroplasticity and responsive to acute physical exercise, providing a link between exercise and brain health. Lactate, a metabolite related to exercise, has been proposed as a potential mediator of the BDNF exercise response; however, lactate's role in isolation has not yet been determined. To investigate this, 18 young, healthy volunteers (50% female) were recruited to donate blood and muscle before, during, and after a 1-h venous infusion of sodium lactate (125 μmol × kg FFM
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