Evidence map›Paper›PMID 41063966›Full record

ArticleFrontiers in cell and developmental biology2025

IL-6 trans-signaling in cystic fibrosis bronchial cells potentiates TNF-α-driven ICAM-1 expression.

John Lin, Lyvia Fourcade, Lucie Roussel, Matthew Marabella, Julie Bérubé, Dao Nguyen, Simon Rousseau

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

John LinThe Meakins-Christie Laboratories at the Research Institute of the McGill University Health Centre and Department of Medicine, McGill University, Montreal, QC, Canada.
Lyvia FourcadeThe Meakins-Christie Laboratories at the Research Institute of the McGill University Health Centre and Department of Medicine, McGill University, Montreal, QC, Canada.
Lucie RousselThe Meakins-Christie Laboratories at the Research Institute of the McGill University Health Centre and Department of Medicine, McGill University, Montreal, QC, Canada.
Matthew MarabellaThe Meakins-Christie Laboratories at the Research Institute of the McGill University Health Centre and Department of Medicine, McGill University, Montreal, QC, Canada.
Julie BérubéThe Meakins-Christie Laboratories at the Research Institute of the McGill University Health Centre and Department of Medicine, McGill University, Montreal, QC, Canada.
Dao NguyenThe Meakins-Christie Laboratories at the Research Institute of the McGill University Health Centre and Department of Medicine, McGill University, Montreal, QC, Canada.
Simon RousseauThe Meakins-Christie Laboratories at the Research Institute of the McGill University Health Centre and Department of Medicine, McGill University, Montreal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: sIL-6Ra expression was measured by ELISA in plasma samples from pwCF at baseline and during exacerbations. IL-6 signalling was investigate in CF and non-CF cell lines using immunoblotting of STAT3 phosphorylation. ICAM-1 cell surface expression was determined using flow cytometry. Results: We show that pwCF had higher sIL-6Rα levels in their plasma during PEx, suggestive of IL-6 trans-signaling. Furthermore, we show that a CF bronchial cell line is hyper-responsive to both classic and trans-signaling, with the higher levels of activation occurring during trans-signaling when compared to two non-CF cell lines. Discussion: Our data unveiled that ICAM-1, which promotes neutrophil adhesion, is upregulated by the combination of TNF-α and IL-6 signaling in CF bronchial cells. Interestingly, soluble IL-6R (sIL-6Rα) protects IL-6 from degradation by bacterial proteases. Therefore, we suggest that strategies which target IL-6 trans-signaling may alleviate ICAM-1 mediated neutrophil adhesion and reduce subsequent lung damage in PEx.

Indexed as

cystic fibrosiscystic fibrosis transmembrane regulatorICAM-1IL-6 trans-signalinginflammationPseudomonas aeruginosapulmonary exacerbations

Identifiers

PMID41063966
PMCPMC12500550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.