ReviewCureus2025
Cerebral Oxygenation Monitoring Using Near-Infrared Spectroscopy in Delivery Room Resuscitation of Neonates: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review evaluates near-infrared spectroscopy (NIRS) in monitoring cerebral oxygenation during neonatal delivery room resuscitation. The objective was to assess its impact on cerebral regional oxygen saturation (CrSO₂), intraventricular hemorrhage (IVH) incidence, and time to stabilization compared to standard protocols. Using a Population, Intervention, Comparison, Outcome (PICO) framework, we searched PubMed, Embase, Cochrane Library, Scopus, and Web of Science from January 2010 to July 2025 for randomized controlled trials (RCTs) and observational studies in English, focusing on term and preterm neonates requiring resuscitation. Exclusions included non-human studies, non-English articles, case reports, and non-delivery room settings. Two reviewers screened 3,500 studies, with 700 remaining after deduplication, and four high-quality primary studies were included after rigorous selection. Quality was assessed using the Cochrane Risk of Bias Tool for RCTs and the Newcastle-Ottawa Scale for observational studies. Due to heterogeneity in study designs, NIRS devices, and outcomes, a narrative synthesis was conducted. Results showed NIRS feasibility, with CrSO₂ rising from 36-37% at one minute to 52-84% by seven to 15 minutes in preterm neonates. One RCT reported a 55.4% reduction in cerebral hypoxia burden (p<0.05), and one cohort study showed lower CrSO₂ in neonates with IVH (p=0.003). IVH incidence was 4-12% (50% in one study), with limited control group data. Stabilization time data were limited. No studies addressed India's high-risk neonatal population or long-term outcomes. NIRS shows promise for optimizing cerebral oxygenation and identifying IVH risk, but larger RCTs, standardized protocols, and India-specific studies are needed.
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Registered trials
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