Evidence map›Paper›PMID 41063825›Full record

ArticleCase reports in ophthalmology

Young-Onset Central Retinal Vein Occlusion with Antiphospholipid Syndrome and Hypophysitis.

Mariko Kawata, Hiromasa Sawamura, Shuichiro Aoki, Kohdai Kitamoto, Yurika Aoyama, Ryo Terao, Tatsuya Inoue, Ryo Obata, Keiko Azuma

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mariko KawataDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Hiromasa SawamuraDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Shuichiro AokiDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Kohdai KitamotoDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Yurika AoyamaDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Ryo TeraoDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Tatsuya InoueDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Ryo ObataDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Keiko AzumaDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The aim of the study was to describe a rare case of central retinal vein occlusion (CRVO) in an adolescent with primary antiphospholipid syndrome (APS) and coexisting lymphocytic hypophysitis (LH). Case Presentation: A 17-year-old female presented with acute vision loss in the right eye and was diagnosed with CRVO. She had no cardiovascular risk factors. Fundoscopy revealed optic disc swelling, macular exudates, and venous dilation. Fluorescein angiography demonstrated optic disc leakage without any signs of vasculitis. IgG anticardiolipin antibodies were persistently elevated on two separate occasions, thereby fulfilling the 2023 ACR/EULAR criteria for APS. Magnetic resonance imaging revealed pituitary stalk thickening and asymmetrical intrasellar enhancement, consistent with LH, although visual field loss and optic nerve abnormalities were not detected. A single intravitreal injection of ranibizumab was effective, resulting in complete resolution of serous retinal detachment and improvement in visual acuity. Anticoagulants were also administered. At the 12-month follow-up, no progression of LH was observed. Conclusion: Coagulation should be thoroughly evaluated in cases of early-onset CRVO without systemic risk factors. This case highlights the importance of considering APS in young patients with CRVO without systemic risk factors. There is a shared immunologic predisposition when coexisting autoimmune disorders such as LH.

Indexed as

AdolescentAntiphospholipid syndromeAutoimmune diseaseCentral retinal vein occlusionHypercoagulabilityLymphocytic hypophysitis

Identifiers

PMID41063825
PMCPMC12503844

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.