Evidence map›Paper›PMID 41063823›Full record

ArticleCase reports in ophthalmology

Vision Restoration of Steroid-Refractory Prelaminar Optic Nerve Inflammation with Plasmapheresis: Report of Two Cases and Literature Review.

Nazanin Ebrahimiadib, Ghazal Ghochani, Samira Yadegari, Bryce E Buchowicz, Sahel Soltani Shahgholi, Afsaneh Azarkish, Hanieh Niktinat, Hamid Riazi-Esfahani, Narges Hassanpoor

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nazanin EbrahimiadibDepartment of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL, USA.
Ghazal GhochaniDepartment of Ophthalmology, Tehran University of Medical Sciences, Tehran, Iran.
Samira YadegariDepartment of Ophthalmology, Tehran University of Medical Sciences, Tehran, Iran.
Bryce E BuchowiczDepartment of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL, USA.
Sahel Soltani ShahgholiDepartment of Ophthalmology, Tehran University of Medical Sciences, Tehran, Iran.
Afsaneh AzarkishDepartment of Ophthalmology, Tehran University of Medical Sciences, Tehran, Iran.
Hanieh NiktinatDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Hamid Riazi-EsfahaniDepartment of Ophthalmology, Tehran University of Medical Sciences, Tehran, Iran.
Narges HassanpoorRetina & Vitreous Service, Nikookari Eye Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Inflammation of the prelaminar compartment of the optic nerve involves the most anterior segment of the nerve. It can occur in isolation, in the setting of immunological or demyelinating disorders. Case Presentation: We present two 32- and 41-year-old female patients with sequential bilateral isolated prelaminar optic neuritis with atypical features. In both instances, plasma exchange (PLEX) was initiated for the second affected eye after corticosteroids proved ineffective, resulting in excellent visual recovery. Both patients lost vision in the fellow eye due to a similar attack that was also refractory to steroids. Our cases did not show any associated demyelinating lesions on imaging and did not show biomarkers such as aquaporin-4 or myelin oligodendrocyte glycoprotein (MOG) antibody in serum workup. They were followed for more than 5 years with stable vision in the only eye. Conclusion: In cases of isolated severe progressive prelaminar optic nerve inflammation refractory to steroid treatment, PLEX can be helpful, even if workup is unremarkable for neuromyelitis optica or other systemic and neurologic conditions.

Indexed as

Autoimmune diseaseCorticosteroidOptic nerve inflammationPlasmapheresisPrelaminar optic neuritis

Identifiers

PMID41063823
PMCPMC12503469

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.