ArticleCase reports in ophthalmology
Reversible Opacification of Intraocular Lens in vitro: Case Report.
Article in Case reports in ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: We reported a case of late-onset opacification of a hydrophilic acrylic intraocular lens (IOL) that developed years after uneventful phacoemulsification cataract surgery. Remarkably, the calcification-related opacification was successfully reversed in vitro using ethylenediaminetetraacetic acid (EDTA) solution. Case Presentation: An 86-year-old male presented with a 2-year history of progressive visual decline in the right eye (best-corrected visual acuity: 2/200). Slit-lamp examination revealed posterior capsular opacification (PCO), and B-scan ultrasonography showed dense vitreous opacities, precluding fundus and optical coherence tomography (OCT) examinations. He had undergone cataract surgery with implantation of a Rayner monofocal IOL 10 years ago. As for the treatment of vitreous opacities, PCO, as well as investigating fundus diseases, the pars plana vitrectomy was performed. After PCO removal, fundus visualization remained poor. Intraoperative inspection revealed diffuse opacification of the IOL, which was subsequently explanted. Following removal of IOL, fundus examination revealed non-proliferative diabetic retinopathy and asteroid hyalosis. In vitro, the IOL exhibited homogeneous opacification resistant to mechanical cleaning and soaking in sterile water for 1 week. However, immersion in 4% EDTA gradually restored full optical clarity over the course of 1 month. Scanning electron microscopy (SEM) demonstrated small subsurface pits suggestive of prior crystal deposition. Energy-dispersive X-ray spectroscopy detected mainly carbon (C) and oxygen (O), without significant evidence of calcium (Ca), silicon (Si), or phosphorus (P). Conclusions: This case highlighted the potential reversibility of hydrophilic IOL opacification through EDTA chelation, suggesting a promising direction for therapeutic management of IOL calcification in vivo in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.