Evidence map›Paper›PMID 41063575›Full record

ArticleJournal of neurochemistry2025

CysLT

Leonardo Magno Rambo, Quéli Fernandes Lenz, Fernanda Rossatto Temp Fava, Laura Hautrive Milanesi, Joseane Righes Marafiga, Ana Cláudia Jesse, Carlos Fernando Mello

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. CysLTJournal of neurochemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leonardo Magno RamboPrograma de Pós-Graduação em Bioquímica, Universidade Federal do Pampa (UNIPAMPA), Uruguaiana, Rio Grande do Sul, Brazil.ORCID 0000-0002-4769-3663
Quéli Fernandes LenzDepartamento de Fisiologia e Farmacologia, Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
Fernanda Rossatto Temp FavaDepartamento de Fisiologia e Farmacologia, Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
Laura Hautrive MilanesiDepartamento de Fisiologia e Farmacologia, Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
Joseane Righes MarafigaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Ana Cláudia JesseDepartamento de Fisiologia e Farmacologia, Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
Carlos Fernando MelloDepartamento de Fisiologia e Farmacologia, Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 307812/2014-6DOCFIX - FAPERGS/CAPES 09/2012
6 · The paper itself

Abstract

Leukotrienes (LTs) are potent bioactive lipids derived from the 5-lipoxygenase (5-LOX)-mediated metabolism of arachidonic acid (AA). Growing evidence suggests that leukotrienes contribute to the pathophysiology of several inflammatory disorders of the central nervous system. However, the molecular mechanisms by which cysteinyl leukotrienes (CysLTs) facilitate excitatory activity remain poorly understood. Sodium/potassium-ATPase (Na

Indexed as

HippocampusProtein Kinase CReceptors, LeukotrieneSodium-Potassium-Exchanging ATPaseAnimalsLeukotriene D4MaleMiceLeukotriene D4leukotriene D4 receptorProtein Kinase CReceptors, LeukotrieneSodium-Potassium-Exchanging ATPaseimmunoreactivityleukotrienesneurological diseasesPKCsodium pumpwestern blot

Identifiers

PMID41063575
PMCPMC12508703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.