Evidence map›Paper›PMID 41063548›Full record

ArticlePhysiological reports2025

Early adaptation to high-altitude: Mood and cognitive responses at simulated 4500 m.

Ricardo Muller Bottura, Ambra Bisio, Debora Cristina Hipolide

Abstract read
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ricardo Muller BotturaDepartment of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID 0000-0003-1941-2040
Ambra BisioDepartment of Experimental Medicine (DIMES), Università degli Studi di Genova, Genova, Italy.
Debora Cristina HipolideDepartment of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.

Funding

Associação Fundo de Incentivo à Pesquisa (AFIP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brasil (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
6 · The paper itself

Abstract

High-altitude exposure induces hypoxemia, triggering metabolic adjustments to enhance oxygen delivery. This acclimatization process often involves mood changes, cognitive alterations, and Acute Mountain Sickness (AMS) symptoms. This study examined the effects of simulated hypoxia at 4500 m on physiological variables, reaction time, lapses, and mood states. Twenty-three volunteers were exposed to a simulated 4500 m altitude for 4 h in a normobaric hypoxia chamber. Lactate, glucose, SpO

Indexed as

AcclimatizationAdaptation, PhysiologicalAffectAltitudeAltitude SicknessCognitionHypoxiaAdultFemaleHeart RateHumansLactic AcidMaleReaction TimeYoung AdultLactic Acidacclimatizationheart ratehypoxiamountain sicknessoxygen saturation

Identifiers

PMID41063548
PMCPMC12508512

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.