ArticlePlant, cell & environment2026
Bivalent Histone Modifications Orchestrate Temporal Regulation of Glucosinolate Biosynthesis During Wound-Induced Stress Responses in Arabidopsis.
Article in Plant, cell & environment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Bivalent Histone Modifications Orchestrate Temporal Regulation of Glucosinolate Biosynthesis During Wound-Induced Stress Responses in Arabidopsis.Plant, cell & environment · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Glucosinolates (GSLs) are secondary metabolites central to plant defence in the Brassicaceae family. While the role of histone modifications in developmental gene regulation is well studied, their function in stress-induced secondary metabolism remains unclear. Here, we show that GSL biosynthetic genes in Arabidopsis thaliana are regulated by bivalent chromatin bearing both active (histone acetylation) and repressive (H3K27me3) histone marks. Components of the Polycomb Repressive Complex 2 (PRC2), including CLF, SWN and LHP1, suppress GSL gene expression, and their loss enhances GSL accumulation. Genome-wide analyses revealed that indolic and aliphatic GSL genes are enriched with H3K27me3, with indolic genes also marked by active histone acetylation. Time-course transcriptome and metabolite analyses using HPLC following wounding revealed distinct temporal activation patterns, with indolic GSL genes induced during the early phases and aliphatic GSL genes activated at later stages. These findings suggest that bivalent histone modifications orchestrate temporal gene expression of GSL pathways under stress, revealing a previously unrecognised epigenetic mechanism underlying plant metabolic responses to environmental stimuli.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.