Evidence map›Paper›PMID 41063329›Full record

ArticleEuropean journal of medical research2025

Association between the triglyceride glucose-body mass index and cardiometabolic diseases risk in chronic liver disease: a nationwide cohort study.

Tianchen Qian, Pengyao Lin, Qingjing Zhu, Shisong Wang, Yiyun Liu, Jiarong Xie, Lei Xu

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In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Tianchen QianDepartment of Gastroenterology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, China.
Pengyao LinDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Haishu District, Ningbo, 315010, China.
Qingjing ZhuDepartment of Gastroenterology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, China.
Shisong WangDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Haishu District, Ningbo, 315010, China.
Yiyun LiuDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Haishu District, Ningbo, 315010, China.
Jiarong XieDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Haishu District, Ningbo, 315010, China.
Lei XuDepartment of Gastroenterology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, China. xulei22@163.com.

Funding

Key Project of the Ningbo Natural Science Foundation 2024J038National Natural Science Foundation of China 82270602National Natural Science Foundation of China 82300654Ningbo Top Medical and Health Research Program 2023020612
6 · The paper itself

Abstract

backgroundThe association between cardiometabolic diseases and the triglyceride-glucose-body mass index (TyG-BMI) has been proved. However, the relationship between the TyG-BMI and cardiometabolic complications in chronic liver disease (CLD) patients has not been clearly elucidated. We aimed to investigate whether the TyG-BMI and its trajectory are associated with cardiometabolic comorbidities, especially Cardiovascular-Kidney-Metabolic syndrome (CKM) in patients with CLD.

methodsWe obtained data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2020. The exposures were baseline TyG-BMI value at baseline and its change between the first and third waves. The change in TyG-BMI was classified via dynamic time wrapping clustering. The outcomes were CKM syndrome and other cardiometabolic diseases. Adjusted Cox proportional hazards regression was used as the main statistical method.

resultsThere were 765 participants in the CKM cohort, of whom 426 (55.7%) were male and 339 (44.3%) were female. High baseline TyG-BMI values were associated with an HR (95% CI) of 2.404 (1.889-3.060; P < 0.001) for CKM. Compared with those in the steadily low TyG-BMI group, the HR (95%CI) in the steadily high TyG-BMI group was 1.405 (1.051-1.879; P = 0.022), the HR (95% CI) in the increasing TyG-BMI group was 1.602 (1.154-2.223; P = 0.005). Results in other cohorts also confirm the relationship between TyG-BMI and CKM-related diseases.

conclusionBaseline high levels and steadily high or increasing high levels of TyG-BMI are associated with cardiometabolic diseases in CLD patients. Monitoring TyG-BMI might improve the prognosis of patients with CLD.

Indexed as

Blood GlucoseBody Mass IndexCardiovascular DiseasesLiver DiseasesMetabolic SyndromeTriglyceridesAgedChinaChronic DiseaseCohort StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedRisk FactorsBlood GlucoseTriglyceridesCardiovascular-kidney-metabolic syndromeCHARLSChronic liver diseaseTriglyceride-glucose-body mass index

Identifiers

PMID41063329
PMCPMC12506333

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.