Evidence map›Paper›PMID 41063326›Full record

ArticleACR open rheumatology2025

IgG and IgM Anti-Phosphatidylserine/Prothrombin Complex Antibody Detection May Improve Classification Accuracy of Systemic Lupus Erythematosus and Antiphospholipid Antibody Syndrome.

Christina Donath, Sara Kahlown, Liye Suo, Katalin Banki, Andras Perl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACR open rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christina DonathDivision of Rhemuatology and Clinical Immunology Department of Medicine, Norton of Medicine, State University of New York Upstate Medical University, Syracuse, New York.
Sara KahlownDivision of Rhemuatology and Clinical Immunology Department of Medicine, Norton of Medicine, State University of New York Upstate Medical University, Syracuse, New York.
Liye SuoDepartment of Pathology, Norton of Medicine, State University of New York Upstate Medical University, Syracuse, New York.
Katalin BankiDepartment of Pathology, Norton of Medicine, State University of New York Upstate Medical University, Syracuse, New York.ORCID https://orcid.org/0000-0001-7944-3872
Andras PerlDivision of Rhemuatology and Clinical Immunology Department of Medicine, Norton of Medicine, State University of New York Upstate Medical University, Syracuse, New York.ORCID https://orcid.org/0000-0002-5017-1348

Funding

NIH HHS AI072648NIH HHS AI122176NIH HHS AR076092Phillips Lupus and Autoimmunity Center of Excellence
6 · The paper itself

Abstract

objectiveAntiphospholipid antibody (aPL) syndrome (APS) classification requires a thrombotic event and detection of lupus anticoagulant (LAC), anticardiolipin antibodies (aCL), or anti-β

methodsA total of 1,286 patients were tested for presence of IgA, IgG, and IgM anti-phosphatidylserine/prothrombin complex (anti-PS/PT) antibodies along with IgA, IgM, and IgG anti-β

resultsA total of 324 patients with SLE, 88 patients with APS, and 54 patients with concurrent SLE and APS had simultaneous testing for IgA, IgG, and IgM anti-PS/PT, aCL, and anti-β

conclusionThese results demonstrate a significant utility of IgM and IgG anti-PS/PT antibody testing for more precise classification of SLE and more sensitive diagnosis and timely treatment of patients with relevant thrombotic clinical manifestations.

Identifiers

PMID41063326
PMCPMC12507528

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