Evidence map›Paper›PMID 41063307›Full record

ArticleEuropean journal of medical research2025

Prognostic role of creatine kinase-MB in elderly patients with sepsis.

Jingwen Li, Qi Wang, Shuaizheng Che, Zhonghua Wang, Shenglong Chen, Shouhong Wang, Xuebiao Wei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jingwen LiDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial Peoples Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Qi WangDepartment of Cardiology, Fuwai Hospital, National Clinical Research Center for Cardiovascular Diseases, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Shuaizheng CheDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial Peoples Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Zhonghua WangDepartment of Geriatric Intensive Care Medicine, Guangdong Provincial Geriatrics Institute, Guangdong Provincial Peoples Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Shenglong ChenDepartment of Geriatric Intensive Care Medicine, Guangdong Provincial Geriatrics Institute, Guangdong Provincial Peoples Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Shouhong WangDepartment of Geriatric Intensive Care Medicine, Guangdong Provincial Geriatrics Institute, Guangdong Provincial Peoples Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Xuebiao WeiDepartment of Geriatric Intensive Care Medicine, Guangdong Provincial Geriatrics Institute, Guangdong Provincial Peoples Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China. weixuebiao@163.com.

Funding

Clinical unique technology of Guangzhou Grant No. 2023P-TS19Guangdong Province science and Technology program No.KD032024001Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention No.Y0120220151Guang dong Provincial Major Science and Technology Special Project No. KS0120240294National Natural Science Foundation of China No.82002014Natural Science Foundation of Guangdong Province No.2021A1515010107Project of Administration of Traditional Chinese Medicine of Guangdong Province of China No. 20221003
6 · The paper itself

Abstract

backgroundAlthough creatine kinase-MB (CK-MB) is a well-established predictor of myocardial infarction, emerging evidence suggests it has prognostic value in various infections; however, its role in sepsis remains unexplored. This study aims to investigate the predictive value of CK-MB for short-term mortality in elderly patients with sepsis.

methodsA total of 1752 patients aged ≥ 60 with sepsis were included and divided into four groups according to the quartiles of CK-MB within 24 h after ICU admission: < 6.6 (n = 435), 6.6-10.9 (n = 440), 10.9-18.5 (n = 435) and ≥ 18.5 (n = 442). Multivariate analysis was conducted to investigate the association of CK-MB with 28-day mortality and identify the risk factors for CK-MB elevation.

resultsBoth in-hospital (39.1% vs 43.0% vs 51.3% vs 60.4%, P < 0.001) and 28-day mortality (24.7% vs 30.2% vs 40.8% vs 56.3%, P < 0.001) rose progressively with increasing CK-MB levels. Multivariate Cox regression analysis confirmed log

conclusionsIn elderly patients with sepsis, elevated CK-MB level measured upon ICU admission was associated with increased 28-day mortality. The combination of CK-MB and lactic acid levels may enhance risk stratification in sepsis patients.

Indexed as

Creatine Kinase, MB FormSepsisAgedAged, 80 and overBiomarkersFemaleHospital MortalityHumansMaleMiddle AgedPrognosisRisk FactorsBiomarkersCreatine Kinase, MB FormCreatine kinase–MBLactatePrognosisSepsis

Identifiers

PMID41063307
PMCPMC12506418

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.