Evidence map›Paper›PMID 41063262›Full record

ReviewJournal of translational medicine2025

Plant-derived extracellular vesicles: composition, function and clinical potential.

Defa Huang, Jie Chen, Minghong Zhao, Haibin Shen, Qing Jin, Dewang Xiao, Zongbo Peng, Tao Chen, Yilei Zhang, Dingyu Rao and 1 more

Abstract readReview
In one paragraph

Review in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  14. Ipriflavone FromMedComm · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Defa Huang *Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.ORCID 0000-0002-8323-7585
Jie Chen *Department of Laboratory Medicine, The Affiliated Yongchuan Hospital of Chongqing Medical University, ChongqingYongchuan, 402177, China.
Minghong Zhao *Laboratory Medicine, Guizhou Aerospace Hospital, Zunyi, 563100, China.
Haibin ShenLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.
Qing JinLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.
Dewang XiaoThe First School of Clinical Medicine, Gannan Medical University, Ganzhou, 341000, China.
Zongbo PengThe First School of Clinical Medicine, Gannan Medical University, Ganzhou, 341000, China.
Tao ChenThe First School of Clinical Medicine, Gannan Medical University, Ganzhou, 341000, China.
Yilei ZhangThe First School of Clinical Medicine, Gannan Medical University, Ganzhou, 341000, China.
Dingyu RaoDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China. 18329037521@163.com.
Meijin LiuLaboratory Medicine, People's Hospital of Ganzhou Economic Development Zone, Ganzhou, 341000, China. m15083780653@163.com.

Funding

Jiangxi Province Administration of Traditional Chinese Medicine Scienceand Technology Plan Project 2024B0303Jiangxi Provincial Health Commission Technology Plan Project 202510463The Ganzhou Science and Technology Plan Project (2023LNS37081 and GZ2024YLJ137)
6 · The paper itself

Abstract

As membrane structural bodies secreted by cells, extracellular vesicles (EVs) have become a hot topic in the field of plant science in recent years. Plant-derived extracellular vesicles (PDEVs) play a key role in both plant physiological activities and the interaction between plants and the environment. These vesicles are involved in plant growth, development, and response to adversity by delivering signaling molecules, proteins, and other bioactive substances. Current studies have shown that PDEVs also exhibit promising potential for clinical applications, including as drug carriers, vaccine development, and biomarkers for disease diagnosis. In this paper, we review studies related to compositional characterization, isolation and purification methods, biological roles, and clinical applications of PDEVs. We aim to provide a systematic theoretical basis and practical guidance for future studies to promote their application in biomedical fields.

Indexed as

Extracellular VesiclesPlantsBiomarkersHumansBiomarkersBiological roleClinical applicationExtracellular vesicleIsolation techniquePlant

Identifiers

PMID41063262
PMCPMC12506526

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.