ArticleParasites & vectors2025
Acaricidal bioactivity and molecular target analysis of Origanum onites and Ocimum gratissimum essential oils against Haemaphysalis doenitzi ticks.
Article in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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10 authors.
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Abstract
backgroundHaemaphysalis doenitzi is a parasite mainly found on the body surface of birds that is capable of transmitting rickettsiae and borrelia, which can cause serious zoonotic diseases. Chemical acaricides are controversial because they pollute the environment and predispose ticks to resistance. In contrast, plant essential oils (EOs) are favored for their effective acaricide properties and environmental friendliness.
methodsThe constituents of Origanum onites and Ocimum gratissimum EOs were profiled using gas chromatography-mass spectrometry (GC-MS). Acaricidal activities were evaluated by immersing unfed nymphs and adults of H. doenitzi in serial solutions for 5 min and monitoring mortality after 24 h. Enzyme activities (Na⁺/K⁺-ATPase, GST, CarE, AChE) and transcript levels of HDABCE1, HDCYP450a and HD-GSTa were quantified in homogenates of treated survivors. Homology models of the three target proteins were generated and docked with carvacrol and eugenol to predict binding sites and affinities.
resultsGC-MS analysis showed 93.3% of carvacrol in O. onites EO and 66.68% of eugenol in O. gratissimum EO. Immersion test showed that O. onites EO had significant acaricidal activity against nymphs and adults, with median lethal concentration (LC
conclusionsThe results of this study provide important insight into the toxicity mechanisms of ticks, and indicate that carvacrol and O. onites EO can be used as alternatives to chemically synthesized acaricides.
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