Evidence map›Paper›PMID 41063236›Full record

ArticleMolecular horticulture2025

CmVNI2-CmMYB3 module regulates flavonol biosynthesis in response to low temperature in chrysanthemum flower.

Tianhua Jiang, Yahui Sun, Yao Wang, Jiayi Luo, Lei Liu, Hanqin Chen, Yiwei Xue, Lili Wang, Kang Gao, Dongliang Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular horticulture, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tianhua Jiang *Institute of Grassland, Flowers and Ecology, Beijing Academy of Agriculture and Forestry Sciences, Beijing, 100097, China.
Yahui Sun *Institute of Grassland, Flowers and Ecology, Beijing Academy of Agriculture and Forestry Sciences, Beijing, 100097, China.
Yao WangInstitute of Grassland, Flowers and Ecology, Beijing Academy of Agriculture and Forestry Sciences, Beijing, 100097, China.
Jiayi LuoBeijing Key Laboratory of Development and Quality Control of Ornamental Crops, Department of Ornamental Horticulture, College of Horticulture, China Agricultural University, Beijing, 100193, China.
Lei LiuBeijing Key Laboratory of Development and Quality Control of Ornamental Crops, Department of Ornamental Horticulture, College of Horticulture, China Agricultural University, Beijing, 100193, China.
Hanqin ChenCollege of Landscape Architecture, Beijing University of Agriculture, Beijing, 102206, China.
Yiwei XueCollege of International Education, Beijing University of Chemical Technology, Beijing, 100029, China.
Lili WangInstitute of Grassland, Flowers and Ecology, Beijing Academy of Agriculture and Forestry Sciences, Beijing, 100097, China.
Kang GaoInstitute of Grassland, Flowers and Ecology, Beijing Academy of Agriculture and Forestry Sciences, Beijing, 100097, China.
Dongliang ChenInstitute of Grassland, Flowers and Ecology, Beijing Academy of Agriculture and Forestry Sciences, Beijing, 100097, China.
Chao MaBeijing Key Laboratory of Development and Quality Control of Ornamental Crops, Department of Ornamental Horticulture, College of Horticulture, China Agricultural University, Beijing, 100193, China.
Conglin HuangInstitute of Grassland, Flowers and Ecology, Beijing Academy of Agriculture and Forestry Sciences, Beijing, 100097, China. conglinh@126.com.
Chang LuoInstitute of Grassland, Flowers and Ecology, Beijing Academy of Agriculture and Forestry Sciences, Beijing, 100097, China. luochang@baafs.net.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flavonols represent a large subgroup of flavonoids and function as the principal bioactive compounds in tea and medicinal chrysanthemum (Chrysanthemum morifolium) flowers. Low temperature is one of the most significant environmental factors influencing flavonol accumulation. Nevertheless, the regulatory mechanisms governing flavonol biosynthesis in response to low temperature remain predominantly uncharacterized. In this study, we observed decreased flavonol accumulation in chrysanthemum flowers under low-temperature conditions, correlating with reduced expression of the NAC transcription factor VND-INTERACTING2 (VNI2). The suppression of CmVNI2 resulted in diminished flavonol content. DNA affinity purification sequencing and RNA sequencing analyses demonstrated that CmVNI2 directly regulates the expression of CmF3H and CmMYB3, two genes essential for flavonol biosynthesis. In addition, transient overexpression of CmMYB3 in CmVNI2 RNA interference plants restored flavonol accumulation. The study establishes that the CmVNI2-CmMYB3 module plays a crucial role in regulating flavonol biosynthesis in chrysanthemum flowers under low-temperature stress and identifies potential target genes for enhancing the bioactive properties of chrysanthemum as a tea or medicinal herb.

Indexed as

Chrysanthemum morifoliumCmMYB3CmVNI2FlavonolLow temperature

Identifiers

PMID41063236
PMCPMC12509343

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.