Evidence map›Paper›PMID 41063187›Full record

ArticleBiotechnology for biofuels and bioproducts2025

From leaf to blend: CNN-enhanced multi-source feature fusion enables threshold-driven style control in digital tobacco formulation.

Di Wu, Zhongli Ye, Hui Liang, Qian Gu, Guohua Cai, Yan Lin, Yiling Chen, Zechun Liu, Wei Xie, Di Wang and 1 more

Abstract read
In one paragraph

Article in Biotechnology for biofuels and bioproducts, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Di WuTechnology Center, China Tobacco Fujian Industrial Co., Ltd., Xiamen, 361021, Fujian, China.
Zhongli YeTechnology Center, China Tobacco Fujian Industrial Co., Ltd., Xiamen, 361021, Fujian, China.
Hui LiangTechnology Center, China Tobacco Fujian Industrial Co., Ltd., Xiamen, 361021, Fujian, China.
Qian GuTechnology Center, China Tobacco Fujian Industrial Co., Ltd., Xiamen, 361021, Fujian, China.
Guohua CaiTechnology Center, China Tobacco Fujian Industrial Co., Ltd., Xiamen, 361021, Fujian, China.
Yan LinTechnology Center, China Tobacco Fujian Industrial Co., Ltd., Xiamen, 361021, Fujian, China.
Yiling ChenTechnology Center, China Tobacco Fujian Industrial Co., Ltd., Xiamen, 361021, Fujian, China.
Zechun LiuTechnology Center, China Tobacco Fujian Industrial Co., Ltd., Xiamen, 361021, Fujian, China.
Wei XieTechnology Center, China Tobacco Fujian Industrial Co., Ltd., Xiamen, 361021, Fujian, China.
Di WangZhengzhou Tobacco Research Institute of CNTC, Zhengzhou, 450001, Henan, China. wangdi@ztri.com.cn.
Qiaoling LiTechnology Center, China Tobacco Fujian Industrial Co., Ltd., Xiamen, 361021, Fujian, China. lql10684@fjtic.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study establishes a computational framework for predictive style modeling in tobacco formulation design, addressing the critical disconnect between empirical approaches and blended system complexity. Herein, "style" refers to the characteristic sensory profiles (e.g., aroma, taste, and physiological sensations) intrinsically linked to cultivation regions, which arise from the unique combination of local environmental factors, such as climate and soil composition. A convolutional neural network (CNN) framework was developed to integrate conventional chemical indicators with thermogravimetric analysis-derived features from 434 geographically authenticated tobacco leaf samples. Through regionally constrained Monte Carlo sampling of composition ratios, 304,800 formulation data sets simulating real-world blending constraints were generated to enable robust model training.

resultsThe leaf-centric CNN demonstrated remarkable region-style classification accuracy (99.54% via fivefold cross-validation), outperforming conventional machine learning models and revealing thermal-chemical complementarity in regional style characterization. However, direct application to blended formulations revealed a critical limitation: only 50.91% of blended formulations maintained stylistic consistency with their primary source leaves, underscoring the inadequacy of single-leaf model for blended systems. To overcome this, a unified CNN framework was trained on a consolidated multi-source data set encompassing both raw leaves and engineered blends, leveraging their shared feature space. This hybrid learning model achieved dual breakthroughs in regional style identification accuracy (90.09%) and leaf-to-blend style consistency (87.90%). Mechanistic analysis identified a nonlinear threshold effect, showing that primary source leaves maintained 99.91% stylistic dominance when exceeded 90% composition, decreasing to 67.90% at 30% composition. Significant formulation style deviation risks emerged when compositional gaps between principal and secondary source leaves narrowed below 10%.

conclusionsBuilding on these insights, a probabilistic style modulation strategy was proposed and validated through case applications, transforming theoretical discoveries into actionable design strategies. This innovation establishes region ratio constraints based on threshold-defined boundaries, creating a data-driven framework that systematically achieves target formulation style through the threshold's predictive capacity. This framework advances tobacco engineering from empirical practices to predictive digital transformation, providing a template for agricultural product manufacturing systems facing similar formulation challenges.

Indexed as

Convolutional neural network (CNN)Formulation style controlMulti-source feature fusionRegional style classification

Identifiers

PMID41063187
PMCPMC12509381

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.